ArticleInternational urogynecology journal2014
Changes in elastin density in different locations of the vaginal wall in women with pelvic organ prolapse.
Article in International urogynecology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Stem cell research & therapy · 2024Article
- The study of vaginal wall thickness in adults based on histopathological measurements.Scientific reports · 2024Article
- Mechanical stress influences the morphology and function of human uterosacral ligament fibroblasts and activates the p38 MAPK pathway.International urogynecology journal · 2022Article
- Molecular mechanism of extracellular matrix disorder in pelvic organ prolapses.Molecular medicine reports · 2020Article
- Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts.International journal of molecular sciences · 2020Article
- A case of mesh erosion in the ureter eight years after a tension-free vaginal mesh surgery.International urogynecology journal · 2019Article
- Neurovascular alterations of muscularis propria in the human anterior vaginal wall in pelvic organ prolapse.Journal of anatomy · 2019Article
- First delivery and ovariectomy affect biomechanical and structural properties of the vagina in the ovine model.International urogynecology journal · 2019Article
- Immunolocalization of Advanced Glycation End Products, Mitogen Activated Protein Kinases, and Transforming Growth Factor-β/Smads in Pelvic Organ Prolapse.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Long term Follow-up of Transvaginal Anatomical Implant of Mesh in Pelvic organ prolapse.Scientific reports · 2018Article
- Hypoxia Induces Apoptosis through HIF-1BioMed research international · 2017Article
- Elastin density: Link between histological and biomechanical properties of vaginal tissue in women with pelvic organ prolapse?International urogynecology journal · 2016Article
- Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content.Scientific reports · 2016Article
- Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse.European journal of histochemistry : EJH · 2016Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThe purpose of this study was to analyze the histomorphometric properties of the vaginal wall in women with pelvic organ prolapse (POP).
methodsIn 15 women undergoing surgery for POP, full-thickness biopsies were collected at two different sites of location from the anterior and/or posterior vaginal wall. Properties of the precervical area (POP-Q point C/D) were compared with the most distal portion of the vaginal wall (POP-Q point Ba/Bp) using histological staining and immunohistochemistry. The densities of total collagen fibers, elastic fibers, smooth muscle cells, and blood vessels were determined by combining high-resolution virtual imaging and computer-assisted digital image analysis.
resultsThe mean elastin density was significantly decreased in the lamina propria and muscularis layer of the vaginal wall from the most distal portion of the prolapsed vaginal wall compared with the precervical area. This difference was statistically significant in the lamina propria for both anterior (8.4 ± 1.2 and 12.1 ± 2.0, p = 0.048) and posterior (6.8 ± 0.5 and 10.1 ± 1.4, p = 0.040) locations, and in the muscularis for the anterior (5.2 ± 0.4 and 8.4 ± 1.2, p = 0.009) vaginal wall. There were no statistically significant differences in the mean densities of collagen fibers, smooth muscle cells or blood vessels between the two locations.
conclusionsIn this study, we observed changes in elastin density in two different locations of the vaginal wall from women with POP. The histomorphometric properties of the vaginal wall can be variable from one place to another in the same patient. This result supports the existence of most vulnerable locations within the vaginal wall and the potential benefit of site-specific prolapse surgery.
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