Evidence map›Paper›PMID 24865642›Full record

ArticleEmerging infectious diseases2014

Short-term malaria reduction by single-dose azithromycin during mass drug administration for trachoma, Tanzania.

Stephen E Schachterle, George Mtove, Joshua P Levens, Emily Clemens, Lirong Shi, Amrita Raj, J Stephen Dumler, Beatriz Munoz, Shelia West, David J Sullivan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Antibiotics for trachoma.The Cochrane database of systematic reviews · 2019
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  12. Anthropometry and Malaria among Children in Niger: A Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Stephen E Schachterle
George Mtove
Joshua P Levens
Emily Clemens
Lirong Shi
Amrita Raj
J Stephen Dumler
Beatriz Munoz
Shelia West
David J Sullivan
Johns Hopkins University · USNational Institute for Medical Research · TZPfizer (United States) · US

Funding

HIV Prevention Trials Network: Network LaboratoryU01AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ESHLEMAN, SUSAN H · 2006 to 2010
$16.5M
NIAID NIH HHS U01 AI068613
6 · The paper itself

Abstract

Single-dose mass drug administration of azithromycin (AZT) is underway to eliminate trachoma worldwide. Studies in Ethiopia showed a reduction in all-cause childhood deaths after administration. To examine the effect of single-dose AZ MDA on prevalent malaria infections in a large prospective cohort of children and parents in Dodoma Province, Tanzania, we quantified the temporal prevalence of malaria parasitemia by real-time PCR for 6 months after single-dose AZT. In the first month after treatment but not in subsequent months, Plasmodium falciparum infections were reduced by 73% (95% CI 43%-89%) in treatment versus control villages and differences remained significant (p = 0.00497) in multivariate models with village-level random effects. Genetic sequencing of P. falciparum ribosomal L4 protein showed no mutations associated with AZT resistance. AZT mass drug administration caused a transient, 1-month antimalarial effect without selecting for P. falciparum ribosomal L4 resistance mutations in a region with a 10-year history of treating trachoma with this drug.

Indexed as

Anti-Bacterial AgentsAzithromycinChildChild, PreschoolChlamydia trachomatisDrug Administration ScheduleFemaleHumansInfantMalaria, FalciparumMalePlasmodium falciparumProtozoan ProteinsRibosomal ProteinsTanzaniaTime FactorsAnti-Bacterial AgentsAzithromycinProtozoan ProteinsRibosomal Proteinsazithromycinmalariamass drug administrationparasitesprospective cohort studysingle doseTanzaniatrachoma

Identifiers

PMID24865642
PMCPMC4036785
OpenAlexW2084277433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.