ArticleNMR in biomedicine2014
Metabolic spectroscopy of inflammation in a bleomycin-induced lung injury model using hyperpolarized 1-(13) C pyruvate.
Article in NMR in biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- HyperpolarizedNMR in biomedicine · 2021Review
- Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation.Frontiers in physiology · 2020Review
- Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer: First Experience in a Canine Prostate Cancer Model.Molecular imaging and biology · 2019Article
- Detection of lung transplant rejection in a rat model using hyperpolarized [1-NMR in biomedicine · 2019Article
- Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.Magnetic resonance in medicine · 2018Article
- Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach.Scientific reports · 2018Article
- In vivo imaging of the progression of acute lung injury using hyperpolarized [1-Magnetic resonance in medicine · 2017Article
- The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging.Advanced drug delivery reviews · 2017Review
- Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine.Scientific reports · 2016Article
- Differentiating inflamed and normal lungs by the apparent reaction rate constants of lactate dehydrogenase probed by hyperpolarized (13)C labeled pyruvate.Quantitative imaging in medicine and surgery · 2016Article
- Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI.Molecular imaging and biology · 2015Article
- The effect of exogenous substrate concentrations on true and apparent metabolism of hyperpolarized pyruvate in the isolated perfused lung.NMR in biomedicine · 2014Article
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Authors and funding
10 authors.
Funding
Abstract
Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall apparent activity of lactate dehydrogenase is shown to increase significantly (on average by a factor of 3.3) at the 7 day acute stage and to revert substantially to baseline at 21 days, while other markers indicating monocarboxylate uptake and transamination rate are unchanged. Elevated lung lactate signal levels correlate well with phosphodiester levels as determined with (31) P spectroscopy and with the presence of neutrophils as determined by histology, consistent with a relationship between intracellular lactate pool labeling and the density and type of inflammatory cells present. We discuss several alternate hypotheses, and conclude that the most probable source of the observed signal increase is direct uptake and metabolism of pyruvate by inflammatory cells and primarily neutrophils. This signal is seen in high contrast to the low baseline activity of the lung.
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