Evidence map›Paper›PMID 24865593›Full record

ArticleTranslational psychiatry2014

Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.

V Douet, L Chang, A Pritchett, K Lee, B Keating, H Bartsch, T L Jernigan, A Dale, N Akshoomoff, S Murray and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Lifetime surgical exposure, episodic memory, and forniceal microstructure in older adults.Journal of clinical and experimental neuropsychology · 2019
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 1 country.

V DouetDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
L ChangDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
A PritchettDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
K LeeDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
B KeatingDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
H BartschDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
T L Jernigan1] Department of Radiology, University of California, San Diego, La Jolla, CA, USA [2] Department of Psychiatry and Department of Cognitive Science, Center for Human Development, University of California, San Diego, La Jolla, CA, USA.
A Dale1] Department of Radiology, University of California, San Diego, La Jolla, CA, USA [2] Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
N Akshoomoff1] Department of Radiology, University of California, San Diego, La Jolla, CA, USA [2] Department of Psychiatry and Department of Cognitive Science, Center for Human Development, University of California, San Diego, La Jolla, CA, USA.
S MurrayScripps Genomic Medicine and Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA, USA.
C BlossScripps Genomic Medicine and Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA, USA.
D N KennedyDepartment of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA.
D AmaralDepartments of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA.
J GruenDepartments of Pediatrics and Investigative Medicine, Child Health Research Center, Yale University School of Medicine, New Haven, CT, USA.
W E KaufmannBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
B J CaseySackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY, USA.
E SowellDepartment of Pediatrics, University of Southern California, and Children's Hospital, Los Angeles, CA, USA.
T ErnstDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
University of California, San Diego · USUniversity of Hawaii System · USQueen's Medical Center · USScripps Research Institute · USCornell University · USHarvard University · USUniversity of California, Davis · USUniversity of Hawaiʻi at Mānoa · USUniversity of Massachusetts Chan Medical School · USUniversity of Southern California · USYale University · US

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
RESEARCH DESIGN, BIOSTATISTICS AND RESEARCH ETHICS COREG12MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 2012 to 2016
$13.0M
Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
Imaging Studies in Neurotoxicity and NeurodevelopmentU54NS056883 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI CHANG, LINDA · 2007 to 2011
$8.4M
Exposing the Deep Content of the Publication: Knowledge Extraction for Neuroimaging in Child PsychiatryR01MH083320 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRAZIER, JEAN A, KENNEDY, DAVID NELSON · 2009 to 2020
$6.3M
Neuroimaging and Mentoring in Drug Abuse ResearchK24DA016170 · NIDA · UNIVERSITY OF HAWAII AT MANOA · PI CHANG, LINDA · 2003 to 2013
$1.8M
NICHD NIH HHS P30 HD018655NIDA NIH HHS 2K24-DA016170NIDA NIH HHS K24 DA016170NIDA NIH HHS RC2 DA029475NIDA NIH HHS RC2-DA29475NIMHD NIH HHS G12 MD007601NIMHD NIH HHS G12-MD007601NIMH NIH HHS R01 MH083320NINDS NIH HHS U54 NS056883NINDS NIH HHS U54NS56883
6 · The paper itself

Abstract

The neuregulin-1 (NRG1) gene is one of the best-validated risk genes for schizophrenia, and psychotic and bipolar disorders. The rs6994992 variant in the NRG1 promoter (SNP8NRG243177) is associated with altered frontal and temporal brain macrostructures and/or altered white matter density and integrity in schizophrenic adults, as well as healthy adults and neonates. However, the ages when these changes begin and whether neuroimaging phenotypes are associated with cognitive performance are not fully understood. Therefore, we investigated the association of the rs6994992 variant on developmental trajectories of brain macro- and microstructures, and their relationship with cognitive performance. A total of 972 healthy children aged 3-20 years had the genotype available for the NRG1-rs6994992 variant, and were evaluated with magnetic resonance imaging (MRI) and neuropsychological tests. Age-by-NRG1-rs6994992 interactions and genotype effects were assessed using a general additive model regression methodology, covaried for scanner type, socioeconomic status, sex and genetic ancestry factors. Compared with the C-carriers, children with the TT-risk-alleles had subtle microscopic and macroscopic changes in brain development that emerge or reverse during adolescence, a period when many psychiatric disorders are manifested. TT-children at late adolescence showed a lower age-dependent forniceal volume and lower fractional anisotropy; however, both measures were associated with better episodic memory performance. To our knowledge, we provide the first multimodal imaging evidence that genetic variation in NRG1 is associated with age-related changes on brain development during typical childhood and adolescence, and delineated the altered patterns of development in multiple brain regions in children with the T-risk allele(s).

Indexed as

HeterozygoteAdolescentAdolescent DevelopmentAdultBrainChildChild DevelopmentChild, PreschoolDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMemory, EpisodicNeuregulin-1Polymorphism, Single NucleotideNeuregulin-1

Identifiers

PMID24865593
PMCPMC4035723
OpenAlexW2157848295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.