Evidence map›Paper›PMID 24865312›Full record

Trial reportRadiology2014

Myocardial CT perfusion imaging and SPECT for the diagnosis of coronary artery disease: a head-to-head comparison from the CORE320 multicenter diagnostic performance study.

Richard T George, Vishal C Mehra, Marcus Y Chen, Kakuya Kitagawa, Armin Arbab-Zadeh, Julie M Miller, Matthew B Matheson, Andrea L Vavere, Klaus F Kofoed, Carlos E Rochitte and 8 more

Erratum issued Registry-linked trialOpen access · greenAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03324308 (The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease), which is not on this map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03324308 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

The Safety, Feasibility and Accuracy of Dynamic Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease

TypeinterventionalSponsorJohns Hopkins UniversityRan2018 to 2022Enrolled0ConditionsCoronary Artery Disease, IschemiaArmsComputed Tomography Angiography
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 131 citations in OpenAlex.

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  17. Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  18. Computed tomography calls out nuclear imaging in its field: It doesn't matter how you are searching but what you are looking for.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Richard T GeorgeFrom the School of Medicine, Johns Hopkins University, 600 N Wolfe St, Blalock 524D2, Baltimore, MD 21287 (R.T.G., V.C.M., A.A.Z., J.M.M., A.L.V., J.A.C.L.); Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Md (M.B.M., C.C.); Department of Nuclear Medicine and Cardiovascular Imaging, Brigham and Women's Hospital, Boston, Mass (M.D.C.); Department of Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil (C.E.R.); National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Md (V.C.M., M.Y.C.); Department of Radiology, Iwate Medical University, Morioka, Japan (H.N.); Department of Radiology, St. Luke's International Hospital, Tokyo, Japan (H.N.); Department of Radiology, Mie University Hospital, Tsu, Japan (K.K.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA (M.E.C.); Department of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (K.F.K.); Department of Cardiology, National Heart Center, Singapore, Singapore (T.S.Y.); and Departments of Radiology (M.D.C.) and Nuclear Medicine (W.B.), Charité-University Medicine Berlin, Berlin, Germany.
Vishal C Mehra
Marcus Y Chen
Kakuya Kitagawa
Armin Arbab-Zadeh
Julie M Miller
Matthew B Matheson
Andrea L Vavere
Klaus F Kofoed
Carlos E Rochitte
Marc Dewey
Tan S Yaw
Hiroyuki Niinuma
Winfried Brenner
Christopher Cox
Melvin E Clouse
João A C Lima
Marcelo Di Carli
Johns Hopkins University · USNational Heart Lung and Blood Institute · US

Funding

Cardiovascular CT ResearchZIAHL006138 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2011 to 2016
$7.3M
Intramural NIH HHS ZIA HL006138
6 · The paper itself

Abstract

purposeTo compare the diagnostic performance of myocardial computed tomographic (CT) perfusion imaging and single photon emission computed tomography (SPECT) perfusion imaging in the diagnosis of anatomically significant coronary artery disease (CAD) as depicted at invasive coronary angiography. MATERIALS AND

methodsThis study was approved by the institutional review board. Written informed consent was obtained from all patients. Sixteen centers enrolled 381 patients from November 2009 to July 2011. Patients underwent rest and adenosine stress CT perfusion imaging and rest and either exercise or pharmacologic stress SPECT before and within 60 days of coronary angiography. Images from CT perfusion imaging, SPECT, and coronary angiography were interpreted at blinded, independent core laboratories. The primary diagnostic parameter was the area under the receiver operating characteristic curve (Az). Sensitivity and specificity were calculated with use of prespecified cutoffs. The reference standard was a stenosis of at least 50% at coronary angiography as determined with quantitative methods.

resultsCAD was diagnosed in 229 of the 381 patients (60%). The per-patient sensitivity and specificity for the diagnosis of CAD (stenosis ≥50%) were 88% (202 of 229 patients) and 55% (83 of 152 patients), respectively, for CT perfusion imaging and 62% (143 of 229 patients) and 67% (102 of 152 patients) for SPECT, with Az values of 0.78 (95% confidence interval: 0.74, 0.82) and 0.69 (95% confidence interval: 0.64, 0.74) (P = .001). The sensitivity of CT perfusion imaging for single- and multivessel CAD was higher than that of SPECT, with sensitivities for left main, three-vessel, two-vessel, and one-vessel disease of 92%, 92%, 89%, and 83%, respectively, for CT perfusion imaging and 75%, 79%, 68%, and 41%, respectively, for SPECT.

conclusionThe overall performance of myocardial CT perfusion imaging in the diagnosis of anatomic CAD (stenosis ≥50%), as demonstrated with the Az, was higher than that of SPECT and was driven in part by the higher sensitivity for left main and multivessel disease.

Indexed as

AgedAged, 80 and overCoronary AngiographyCoronary Artery DiseaseFemaleHumansMaleMiddle AgedMyocardial Perfusion ImagingProspective StudiesTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed

Identifiers

PMID24865312
PMCPMC4263655
OpenAlexW2158796348

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.