ArticleBioMed research international2014
Effects of canonical NF-κB signaling pathway on the proliferation and odonto/osteogenic differentiation of human stem cells from apical papilla.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Osteogenic Differentiation and Proliferation of Apical Papilla Stem Cells Using Chitosan-Coated Nanohydroxyapatite and Bioactive Glass Nanoparticles.European journal of dentistry · 2024Article
- Exploring the impact of oral bacteria remnants on stem cells from the Apical papilla: mineralization potential and inflammatory response.Frontiers in cellular and infection microbiology · 2023Article
- P75 neurotrophin receptor positively regulates the odontogenic/osteogenic differentiation of ectomesenchymal stem cells via nuclear factor kappa-B signaling pathway.Bioengineered · 2022Article
- Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate-based cements by RNA sequencing.Clinical oral investigations · 2021Article
- Anacardic acid-mediated regulation of osteoblast differentiation involves mitigation of inflammasome activation pathways.Molecular and cellular biochemistry · 2021Article
- Role and application of stem cells in dental regeneration: A comprehensive overview.EXCLI journal · 2021Review
- GATA Binding Protein 4 Regulates Tooth Root Dentin DevelopmentInternational journal of biological sciences · 2020Article
- Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells.Stem cell research & therapy · 2019Article
- High Glucose Enhances the Odonto/Osteogenic Differentiation of Stem Cells from Apical Papilla via NF-KappaB Signaling Pathway.BioMed research international · 2019Article
- Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy.BioMed research international · 2019Review
- The Conditioned Medium of Calcined Tooth Powder Promotes the Osteogenic and Odontogenic Differentiation of Human Dental Pulp Stem Cells via MAPK Signaling Pathways.Stem cells international · 2019Article
- Yunnan Baiyao Conditioned Medium Promotes the Odonto/Osteogenic Capacity of Stem Cells from Apical Papilla via Nuclear Factor Kappa B Signaling Pathway.BioMed research international · 2019Article
- Proliferation, odontogenic/osteogenic differentiation, and cytokine production by human stem cells of the apical papilla induced by biomaterials: a comparative study.Clinical, cosmetic and investigational dentistry · 2019Article
- Stem Cells From the Apical Papilla (SCAP) as a Tool for Endogenous Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2018Review
- Spreading, proliferation and differentiation of human dental pulp stem cells on chitosan scaffolds immobilized with RGD or fibronectin.Cytotechnology · 2017Article
- GATA4 regulates osteoblastic differentiation and bone remodeling via p38-mediated signaling.Journal of molecular histology · 2017Article
- Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3.Scientific reports · 2017Article
- Two novel BMP-2 variants identified in patients with thoracic ossification of the ligamentum flavum.European journal of human genetics : EJHG · 2017Article
- Osteopontin stimulates matrix metalloproteinase expression through the nuclear factor-κB signaling pathway in rat temporomandibular joint and condylar chondrocytes.American journal of translational research · 2017Article
- IGF-1/IGF-1R/hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background informationNF-κB signaling pathway plays a complicated role in the biological functions of mesenchymal stem cells. However, the effects of NF-κB pathway on the odonto/osteogenic differentiation of stem cells from apical papilla (SCAPs) remain unclear. The present study was designed to evaluate the effects of canonical NF-κB pathway on the osteo/odontogenic capacity of SCAPs in vitro.
resultsWestern blot results demonstrated that NF-κB pathway in SCAPs was successfully activated by TNF-α or blocked by BMS-345541. NF-κB pathway-activated SCAPs presented a higher proliferation activity compared with control groups, as indicated by dimethyl-thiazol-diphenyl tetrazolium bromide assay (MTT) and flow cytometry assay (FCM). Wound scratch assay revealed that NF-κB pathway-activated SCAPs presented an improved migration capacity, enhanced alkaline phosphatase (ALP) activity, and upregulated mineralization capacity of SCAPs, as compared with control groups. Meanwhile, the odonto/osteogenic markers (ALP/ALP, RUNX2/RUNX2, OSX/OSX, OCN/OCN, OPN/OPN, BSP/BSP, DSPP/DSP, and DMP-1/DMP-1) in NF-κB pathway-activated SCAPs were also significantly upregulated as compared with control groups at both protein and mRNA levels. However, NF-κB pathway-inhibited SCAPs exhibited a lower proliferation/migration capacity, and decreased odonto/osteogenic ability in comparison with control groups.
conclusionOur findings suggest that classical NF-κB pathway plays a paramount role in the proliferation and committed differentiation of SCAPs.
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