ArticleBioMed research international2014
Time-lapse dynamics of the mouse oocyte chromatin organisation during meiotic resumption.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes.Journal of developmental biology · 2025Article
- Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status.Journal of assisted reproduction and genetics · 2023Article
- Dynamic of centromere associated RNAs and the centromere loading of DNA repair proteins in growing oocytes.Frontiers in genetics · 2023Article
- Quantitative morphokinetic parameters identify novel dynamics of oocyte meiotic maturation and cumulus expansion†.Biology of reproduction · 2022Article
- A transition phase in late mouse oogenesis impacts DNA methylation of the early embryo.Communications biology · 2022Article
- Effects of the timing of electroporation duringVeterinary and animal science · 2022Article
- TBP-Related Factor 2 as a Trigger for Robertsonian Translocations and Speciation.International journal of molecular sciences · 2020Article
- Review
- H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis.Cell cycle (Georgetown, Tex.) · 2016Article
- TheJournal of reproduction & infertilityArticle
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In the mammalian oocyte, distinct patterns of centromeres and pericentromeric heterochromatin localisation correlate with the gamete's developmental competence. Mouse antral oocytes display two main types of chromatin organisation: SN oocytes, with a ring of Hoechst-positive chromatin surrounding the nucleolus, and NSN oocytes lacking this ring. When matured to MII and fertilised, only SN oocytes develop beyond the 2-cell, and reach full term. To give detailed information on the dynamics of the SN or NSN chromatin during meiosis resumption, we performed a 9 hr time-lapse observation. The main significant differences recorded are: (1) reduction of the nuclear area only in SN oocytes; (2) ~17 min delay of GVBD in NSN oocytes; (3) chromatin condensation, after GVBD, in SN oocytes; (4) formation of 4-5 CHCs in SN oocytes; (5) increase of the perivitelline space, ~57 min later in NSN oocytes; (6) formation of a rosette-like disposition of CHCs, ~84 min later in SN oocytes; (7) appearance of the MI plate ~40 min later in NSN oocytes. Overall, we described a pathway of transition from the GV to the MII stage that is punctuated of discrete recordable events showing their specificity and occurring with different time kinetics in the two types of oocytes.
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