ArticleBioMed research international2014
Evaluation of anti-Candida activity of Vitis vinifera L. seed extracts obtained from wine and table cultivars.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Protective Effect of Procyanidin-Rich Grape Seed Extract against Gram-Negative Virulence Factors.Antibiotics (Basel, Switzerland) · 2023Article
- A New Approach for the Treatment of Recurrent Vulvovaginal Candidiasis with a Combination of Pea Protein, Grape Seed Extract, and Lactic Acid Assessed In Vivo.Journal of fungi (Basel, Switzerland) · 2022Article
- The Antimicrobial Activities of Silver Nanoparticles from Aqueous Extract of Grape Seeds against Pathogenic Bacteria and Fungi.Molecules (Basel, Switzerland) · 2021Article
- Antifungal Activity of Phenolic and Polyphenolic Compounds from Different Matrices ofMolecules (Basel, Switzerland) · 2020Review
- Renal protective effects of grape seed extract treatment against Eltroxin-induced hyperthyroidism, kidney damage, and oxidative stress in male mice.Environmental science and pollution research international · 2020Article
- Polyphenols fromAntioxidants (Basel, Switzerland) · 2019Article
- Anti-Molecules (Basel, Switzerland) · 2019Article
- Encapsulation of Mentha Oil in Chitosan Polymer Matrix Alleviates Skin Irritation.AAPS PharmSciTech · 2016Article
- Antimicrobial Activity and Phytochemical Analysis of Organic Extracts from Cleome spinosa Jaqc.Frontiers in microbiology · 2016Article
- Oligomeric Procyanidins Interfere with Glycolysis of Activated T Cells. A Novel Mechanism for Inhibition of T Cell Function.Molecules (Basel, Switzerland) · 2015Article
- In Vitro Antimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- In Vivo Anti-Candida Activity of Phenolic Extracts and Compounds: Future Perspectives Focusing on Effective Clinical Interventions.BioMed research international · 2015Review
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the first time, grape seed extracts (GSEs), obtained from wine and table cultivars of Vitis vinifera L., cultured in experimental fields of Lazio and Puglia regions of Italy and grown in different agronomic conditions, have been tested on 43 Candida species strains. We demonstrated a significant correlation between the content of the flavan-3-ols in GSEs extracts, with a polymerization degree ≥ 4, and anti-Candida activity. Moreover, we demonstrated that GSEs, obtained from plants cultured with reduced irrigation, showed a content of polymeric flavan-3-ols >250 mg/g with geometric mean MIC values between 5.7 and 20.2 mg/L against Candida albicans reference strains. GSE, showing 573 mg/g of polymeric flavan-3-ols, has been tested in an experimental murine model of vaginal candidiasis by using noninvasive in vivo imaging technique. The results pointed out a significant inhibition of Candida albicans load 5 days after challenge. These findings indicate that GSEs with high content of polymeric flavan-3-ols can be used in mucosal infection as vaginal candidiasis.
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