ArticleMolecular psychiatry2015
FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet.
Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 77 citations in OpenAlex.
- Genetic Variants Influencing Taste Perception and Food Preferences: Current Evidence.Nutrients · 2026Review
- Conserved noncoding cis elements associated with hibernation modulate metabolic and behavioral adaptations in mice.Science (New York, N.Y.) · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Association of FTO variants rs9939609 and rs1421085 with elevated sugar and fat consumption in adult obesity.Scientific reports · 2024Article
- How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank.BMC medicine · 2024Article
- Association between personality traits, eating behaviors, and the genetic polymorphismsFrontiers in genetics · 2024Article
- Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.International journal of epidemiology · 2023Article
- Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases.Genes & diseases · 2023Review
- Technologies, strategies, and cautions when deconvoluting genome-wide association signals: FTO in focus.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- In silico profiling of nonsynonymous SNPs of fat mass and obesity-associated gene: possible impacts on the treatment of non-alcoholic fatty liver disease.Lipids in health and disease · 2023Article
- Increased meso-striatal connectivity mediates trait impulsivity inFrontiers in endocrinology · 2023Article
- Article
- Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index.International journal of environmental research and public health · 2021Article
- Relation of FTO to BOLD response to receipt and anticipated receipt of food and monetary reward, food images, and weight gain in healthy weight adolescents.Social cognitive and affective neuroscience · 2020Article
- Causal graphs for the analysis of genetic cohort data.Physiological genomics · 2020Review
- Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity.Cell reports · 2019Article
- Association between impulsivity traits and body mass index at the observational and genetic epidemiology level.Scientific reports · 2019Observational
- Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population.Brain and behavior · 2019Article
- The role of mRNA mCell & bioscience · 2019Review
- A Metabolic Obesity Profile Is Associated With Decreased Gray Matter Volume in Cognitively Healthy Older Adults.Frontiers in aging neuroscience · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Although overweight and obesity are associated with poor health outcomes in the elderly, the biological bases of obesity-related behaviors during aging are poorly understood. Common variants in the FTO gene are associated with adiposity in children and younger adults as well as with adverse mental health in older individuals. However, it is unclear whether FTO influences longitudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during aging. We examined whether a commonly carried obesity-risk variant in the FTO gene (rs1421085 single-nucleotide polymorphism) influences adiposity and is associated with changes in brain function in participants within the Baltimore Longitudinal Study of Aging, one of the longest-running longitudinal aging studies in the United States. Our results show that obesity-related risk allele carriers of FTO gene show dose-dependent increments in body mass index during aging. Moreover, the obesity-related risk allele is associated with reduced medial prefrontal cortical function during aging. Consistent with reduced brain function in regions intrinsic to impulse control and taste responsiveness, risk allele carriers of FTO exhibit dose-dependent increments in both impulsivity and intake of fatty foods. We propose that a common neural mechanism may underlie obesity-associated impulsivity and increased consumption of high-calorie foods during aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.