ReviewClinical cardiology2014
The role of vitamin supplementation in the prevention of cardiovascular disease events.
Review in Clinical cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.BMJ open · 2018Pooled it
- Vitamin D Supplementation in the Treatment of Chronic Heart Failure: A Meta-analysis of Randomized Controlled Trials.Clinical cardiology · 2016Pooled it
- Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine.Nutrients · 2016Trial
- Myocardial infarction with non-obstructive coronary artery caused by coronary artery spasm and an increase in serum homocysteine: a case report.European heart journal. Case reports · 2025Article
- Joint and independent associations of dietary vitamin intake and prevalence of cardiovascular disease in chronic kidney disease subjects: a cross-sectional analysis.Frontiers in nutrition · 2025Article
- Homocysteine Blood Levels and Mandatory Folic Acid Fortification in Serbia.Current pharmaceutical design · 2025Article
- The Efficacy of Vitamins in the Prevention and Treatment of Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Review
- [Effect of vitamin D deficiency on cardiac autonomic nerve function in obese pre-school children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Importance of Nutrients and Nutrient Metabolism on Human Health.The Yale journal of biology and medicine · 2018Review
- Association of Ischemic Cardiovascular Disease with Inadequacy of Liver Store of Retinol in Elderly Individuals.Oxidative medicine and cellular longevity · 2018Article
- Pyridoxamine improves survival and limits cardiac dysfunction after MI.Scientific reports · 2017Article
- Nutritional Renaissance and Public Health Policy.Journal of nutritional biology · 2017Article
- [Research advances in association between vitamin D and Kawasaki disease and related mechanisms of action].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes.Clinical and translational science · 2016Article
- Redox signaling, Nox5 and vascular remodeling in hypertension.Current opinion in nephrology and hypertension · 2015Review
- Major electrocardiographic abnormalities and 25-hydroxy vitamin D deficiency: insights from National Health and Nutrition Examination Survey-III.Clinical cardiology · 2014Article
- Elevated cardiac markers in chronic kidney disease as a consequence of hyperphosphatemia-induced cardiac myocyte injury.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- The Tibetan herbal medicines Padma 28 and Padma Circosan inhibit the formation of advanced glycation endproducts (AGE) and advanced oxidation protein products (AOPP) in vitro.BMC complementary and alternative medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The production, sale, and consumption of multiple vitamins is a multibillion-dollar industry. Most Americans take some form of supplement ostensibly for prevention of cardiovascular disease. It has been claimed that vitamin A retards atherogenesis. Vitamin C is an antioxidant and is thought to possibly decrease free radical-induced endothelial injury, which can lead to atherosclerotic plaque formation. Vitamin E has been extensively studied for its possible effects on platelet function as well as inhibition of foam-cell formation. Low levels of vitamin D have been thought to negatively impact myocardial structure and increase the risk for cardiovascular events. Increased intake of vitamin B6, B12, and folate has been associated with reduction of homocysteine levels; elevated homocysteine blood levels have been associated with the occurrence of stroke, heart attack, and cardiovascular death. The purpose of this study was to review the currently available literature for vitamin supplementation with respect to prevention of cardiovascular disease. Unfortunately, the current evidence suggests no benefit exists with vitamin supplementation in the general US population. Further research is needed to evaluate whether there are specific populations that might benefit from vitamin supplementation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.