ArticleJournal of neurology, neurosurgery, and psychiatry1989
Do leukocytes have a role in the cerebral no-reflow phenomenon?
Article in Journal of neurology, neurosurgery, and psychiatry, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Capillary stalling: A common microvascular pathway to stroke susceptibility and poor recovery.Neurobiology of disease · 2026Review
- No-reflow after recanalization in ischemic stroke: From pathomechanisms to therapeutic strategies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- The Inflammatory Response After Ischemic Stroke: Targeting βFrontiers in neuroscience · 2019Review
- Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia.Stroke research and treatment · 2013Article
- Regulation of cerebral vasculature in normal and ischemic brain.Neuropharmacology · 2008Review
- Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia.Experimental neurology · 2007Article
- Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.The Journal of clinical investigation · 1996Article
- Article
- No-reflow after cardiac arrest.Intensive care medicine · 1995Article
- Proceedings of the 4th International Symposium on Mechanisms of Secondary Brain Damage -- an update. Abstracts.Acta neurochirurgica · 1993Article
- The effect of immunosuppression on the development of cerebral oedema in an experimental model of intracerebral haemorrhage: whole body and regional irradiation.Journal of neurology, neurosurgery, and psychiatry · 1992Article
- Leucocyte depletion does not affect post-ischaemic nerve cell damage in the rat.Acta neurochirurgica · 1991Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The possible role of leukocytes in the cerebral microcirculation following ischaemia was assessed in the gerbil. The no-reflow phenomenon seen after 30 minutes of severe bilateral hemispheric ischaemia during hypotensive reperfusion was compared in control animals and in a group made leukopenic by pretreatment with cyclophosphamide. Neither the incidence nor the severity of the no-reflow phenomenon differed between the two groups. The evidence from this study casts doubt on the hypothesis that leukocyte plugging plays a major role in the cerebral microcirculation's response to ischaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.