ArticleEvolution; international journal of organic evolution2014
Hormesis results in trade-offs with immunity.
Article in Evolution; international journal of organic evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Metabolic stress as a driver of life-history plasticity: flight promotes longevity and antioxidant production in monarch butterflies.Proceedings. Biological sciences · 2023Article
- Integrative biology of injury in animals.Biological reviews of the Cambridge Philosophical Society · 2023Review
- The anti-tumor efficacy of 20(S)-protopanaxadiol, an active metabolite of ginseng, according to fasting on hepatocellular carcinoma.Journal of ginseng research · 2022Article
- Less Can Be More: The Hormesis Theory of Stress Adaptation in the Global Biosphere and Its Implications.Biomedicines · 2021Review
- Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.Aging cell · 2020Article
- Article
- Plant Hormesis Management with Biostimulants of Biotic Origin in Agriculture.Frontiers in plant science · 2017Review
- Evolution determines how global warming and pesticide exposure will shape predator-prey interactions with vector mosquitoes.Evolutionary applications · 2016Article
- Cadmium Protection Strategies--A Hidden Trade-Off?International journal of molecular sciences · 2016Review
- Cold-seeking behaviour mitigates reproductive losses from fungal infection in Drosophila.The Journal of animal ecology · 2016Article
- Which Is the Most Significant Cause of Aging?Antioxidants (Basel, Switzerland) · 2015Review
- Wolbachia and the insect immune system: what reactive oxygen species can tell us about the mechanisms of Wolbachia-host interactions.Frontiers in microbiology · 2015Review
- Hormetic effect of rotenone in primary human fibroblasts.Immunity & ageing : I & A · 2015Article
- Hormesis and trade-offs: a comment.Dose-response : a publication of International Hormesis Society · 2014Article
- Aging-modulating treatments: from reductionism to a system-oriented perspective.Frontiers in genetics · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost free, artifacts of inbreeding, or come with deleterious side effects. Here, we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines that lack key components of antifungal immunity (Dif and Turandot M). And, in outbred fly lines, we find that topical pathogen challenge enhances both survival and fecundity, but reduces ability to fight off live infections. The results provide evidence that hormesis is manifested by stress-induced trade-offs with immunity, not cost-free benefits or artifacts of inbreeding. Our findings illuminate mechanisms underlying pathogen-induced life-history trade-offs, and indicate that reduced immune function may be an ironic side effect of the "elixirs of life."
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.