ArticleMuscle & nerve2014
Transient hyperckemia in the setting of neuromyelitis optica (NMO).
Article in Muscle & nerve, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Neuromyelitis optica spectrum disorder: Exploring the diverse clinical manifestations and the need for further exploration.Brain and behavior · 2024Review
- Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica.Internal medicine (Tokyo, Japan) · 2020Article
- Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders.Neuropharmacology · 2020Article
- Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder.Internal medicine (Tokyo, Japan) · 2018Article
- The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica.Journal of cellular and molecular medicine · 2018Article
- Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica.Journal of cellular and molecular medicine · 2018Article
- Muscle damage in patients with neuromyelitis optica spectrum disorder.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2017Review
- Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G.Acta neuropathologica communications · 2017Article
- Fatigue in patients with neuromyelitis optica spectrum disorder and its impact on quality of life.PloS one · 2017Article
- Müller cells and retinal axons can be primary targets in experimental neuromyelitis optica spectrum disorder.Clinical & experimental neuroimmunology · 2017Review
- Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G.Journal of neuroinflammation · 2016Article
- Multisystem involvement in neuromyelitis optica.Annals of Indian Academy of Neurology · 2015Article
- The Urine Proteome Profile Is Different in Neuromyelitis Optica Compared to Multiple Sclerosis: A Clinical Proteome Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionNeuromyelitis optica (NMO) is characterized by inflammatory demyelinating lesions of the spinal cord and optic nerves from an autoimmune response against water channel aquaporin-4 (AQP4). We report 2 patients with transient hyperCKemia associated with NMO suggesting possible skeletal muscle damage.
methodsPatient 1 was a 72-year-old man who presented with muscle soreness and elevated serum creatine kinase (CK) preceding an initial attack of NMO. Patient 2 was a 25-year-old woman with an established diagnosis of NMO who presented with diffuse myalgias, proximal upper extremity weakness, and hyperCKemia. Muscle biopsies were obtained for histopathologic evaluation, protein gel electrophoresis, immunofluorescence, and complement staining.
resultsIn both patients the muscle showed only mild variation in fiber diameter. There were no inflammatory changes or muscle fiber necrosis, though there was reduced AQP4 expression and deposition of activated complement.
conclusionsComplement-mediated sarcolemmal injury may lead to hyperCKemia in NMO.
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