Evidence map›Paper›PMID 24862441›Full record

ArticleBiomaterials2014

Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.

Ellen T Roche, Conn L Hastings, Sarah A Lewin, Dmitry Shvartsman, Yevgeny Brudno, Nikolay V Vasilyev, Fergal J O'Brien, Conor J Walsh, Garry P Duffy, David J Mooney

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 154 citations in OpenAlex.

  1. Review
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  5. Delivering living medicines with biomaterials.Nature reviews. Materials · 2025
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ellen T Roche *School of Engineering and Applied Sciences, Harvard University, 29 Oxford street, Cambridge, MA 02138, USA.
Conn L Hastings *Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephens Green, Dublin 2, Ireland.
Sarah A LewinWyss Institute for Biologically Inspired Engineering, 60 Oxford street, Cambridge, MA 02138, USA.
Dmitry ShvartsmanSchool of Engineering and Applied Sciences, Harvard University, 29 Oxford street, Cambridge, MA 02138, USA.
Yevgeny BrudnoSchool of Engineering and Applied Sciences, Harvard University, 29 Oxford street, Cambridge, MA 02138, USA.
Nikolay V VasilyevBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Fergal J O'BrienTissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephens Green, Dublin 2, Ireland.
Conor J WalshSchool of Engineering and Applied Sciences, Harvard University, 29 Oxford street, Cambridge, MA 02138, USA.
Garry P DuffyTissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephens Green, Dublin 2, Ireland.
David J MooneySchool of Engineering and Applied Sciences, Harvard University, 29 Oxford street, Cambridge, MA 02138, USA.
Harvard University · USRoyal College of Surgeons in Ireland · IEBoston Children's Hospital · USInspire Institute · US

Funding

Engineering Capillary NetworksR01HL069957 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOONEY, DAVID J · 2003 to 2013
$4.2M
NHLBI NIH HHS R01 HL069957
6 · The paper itself

Abstract

Cell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate if acute retention can be improved with a biomaterial carrier. Cells were quantified post-implantation in a rat myocardial infarct model in five groups (n = 7-8); saline injection (current clinical standard), two injectable hydrogels (alginate, chitosan/β-glycerophosphate (chitosan/ß-GP)) and two epicardial patches (alginate, collagen). Human mesenchymal stem cells (hMSCs) were delivered to the infarct border zone with each biomaterial. At 24 h, retained cells were quantified by fluorescence. All biomaterials produced superior fluorescence to saline control, with approximately 8- and 14-fold increases with alginate and chitosan/β-GP injectables, and 47 and 59-fold increases achieved with collagen and alginate patches, respectively. Immunohistochemical analysis qualitatively confirmed these findings. All four biomaterials retained 50-60% of cells that were present immediately following transplantation, compared to 10% for the saline control. In conclusion, all four biomaterials were demonstrated to more efficiently deliver and retain cells when compared to a saline control. Biomaterial-based delivery approaches show promise for future development of efficient in vivo delivery techniques.

Indexed as

Mesenchymal Stem Cell TransplantationAlginatesAnimalsBiocompatible MaterialsCells, CulturedCells, ImmobilizedCell SurvivalChitosanCollagenFemaleGlucuronic AcidGlycerophosphatesHexuronic AcidsHumansHydrogelsMesenchymal Stem CellsAlginatesbeta-glycerophosphoric acidBiocompatible MaterialsChitosanCollagenGlucuronic AcidGlycerophosphatesHexuronic AcidsHydrogelsAlginateCell viabilityCollagenHeartHydrogel

Identifiers

PMID24862441
PMCPMC4051834
OpenAlexW1974285372

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.