ArticleObesity (Silver Spring, Md.)2014
Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Changes in adipose tissue depots and metabolic markers following a 1-year diet and exercise intervention in overweight and obese patients with type 2 diabetes.Diabetes care · 2014Trial
- Myosteatosis: an emerging biomarker of aging.Frontiers in aging · 2026Review
- Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.Current obesity reports · 2025Review
- Ethnic diversity in precision medicine: a reality or an aspiration?Diabetologia · 2025Review
- South Asians and cardiometabolic health: A framework for comprehensive care for the individual, community, and population - An American society for preventive cardiology clinical practice statement.American journal of preventive cardiology · 2025Article
- Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer.World journal of gastrointestinal oncology · 2025Article
- Muscle Strength, Genetic Risk, and Type 2 Diabetes Among Individuals of South Asian Ancestry: A UK Biobank Study.Journal of diabetes · 2025Article
- Abdominal fat accumulation increases the risk of high blood pressure: evidence of 47,037 participants from Chinese and US national population surveys.Nutrition journal · 2024Article
- Assessment of body compositions in the prediction of metabolic syndrome in adults.Quantitative imaging in medicine and surgery · 2024Article
- Long-term aspartame and saccharin intakes are related to greater volumes of visceral, intermuscular, and subcutaneous adipose tissue: the CARDIA study.International journal of obesity (2005) · 2023Article
- The mediation and interaction of the obesity index between moderate-vigorous recreational physical activity and hypertension.PloS one · 2023Article
- Replacing sedentary time with light activity was associated with less adiposity across several depots in African ancestry men.Obesity (Silver Spring, Md.) · 2022Article
- Muscle protein synthesis and muscle/metabolic responses to resistance exercise training in South Asian and White European men.Scientific reports · 2022Article
- Trends in general and abdominal obesity in US adults: Evidence from the National Health and Nutrition Examination Survey (2001-2018).Frontiers in public health · 2022Article
- HELICAL COMPUTERIZED TOMOGRAPHY CAN MEASURE SUBCUTANEOUS, VISCERAL AND TOTAL FAT AREAS?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Observational
- Article
- Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men.Obesity science & practice · 2021Article
- Computed Tomography-Derived Myosteatosis and Metabolic Disorders.Diabetes & metabolism journal · 2021Review
- Diabetes and cardiometabolic risk in South Asian youth: A review.Pediatric diabetes · 2021Review
- Association Between Waist Circumference and the Prevalence of (Pre) Hypertension Among 27,894 US Adults.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo compare fat distribution and associations between fat depots and cardiometabolic traits in South Asians and Europeans.
methodsFive hundred and fourteen South Asians and 669 Europeans, aged 56-86. Questionnaires, record review, blood testing, and coronary artery calcification scores provided diabetes and clinical plus subclinical coronary heart disease (CHD) diagnoses. Abdominal visceral (VAT) and subcutaneous adipose tissue, thigh subcutaneous adipose tissue (TSAT), intermuscular and intramuscular thigh fat and thigh muscle were measured by CT.
resultsAccounting for body size, South Asians had greater VAT and TSAT than Europeans, but less thigh muscle. Associations between depots and disease were stronger in South Asians than Europeans. In multivariable analyses in South Asians, VAT was positively associated with diabetes and CHD, while TSAT and thigh muscle were protective for diabetes, and thigh muscle for CHD. Differences in VAT and thigh muscle only partially explained the excess diabetes and CHD in South Asians versus Europeans. Insulin resistance did not account for the effects of TSAT or thigh muscle.
conclusionsGreater VAT and TSAT and lesser thigh muscle in South Asians contributed to ethnic differences in cardiometabolic disease. Effects of TSAT and thigh muscle were independent of insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.