ArticlePsychiatry research2014
Cocaine dependent individuals with attenuated striatal activation during reinforcement learning are more susceptible to relapse.
Article in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.Clinical psychology review · 2021Pooled it
- Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- In Cocaine Dependence, Neural Prediction Errors During Loss Avoidance Are Increased With Cocaine Deprivation and Predict Drug Use.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- Task-dependent increases and decreases of BOLD signal in theory of mind brain regions during strategic social interaction.Frontiers in neural circuits · 2026Article
- Atypical contributions of reward decisions to momentary mood in individuals with methamphetamine use disorder.BMC psychiatry · 2025Article
- Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals.The international journal of neuropsychopharmacology · 2023Article
- Decreased reward-related brain function prospectively predicts increased substance use.Journal of abnormal psychology · 2021Article
- Bouncing back: Brain rehabilitation amid opioid and stimulant epidemics.NeuroImage. Clinical · 2019Review
- Ventral striatal dysfunction in cocaine dependence - difference mapping for subregional resting state functional connectivity.Translational psychiatry · 2018Article
- Tulsa 1000: a naturalistic study protocol for multilevel assessment and outcome prediction in a large psychiatric sample.BMJ open · 2018Observational
- Insular and cingulate attenuation during decision making is associated with future transition to stimulant use disorder.Addiction (Abingdon, England) · 2017Article
- Neural responses to negative outcomes predict success in community-based substance use treatment.Addiction (Abingdon, England) · 2017Article
- Dissociable Effects of Cocaine Dependence on Reward Processes: The Role of Acute Cocaine and Craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- A preliminary study of longitudinal neuroadaptation associated with recovery from addiction.Drug and alcohol dependence · 2016Article
- Brain-based origins of change language: a beginning.Addictive behaviors · 2014Article
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6 authors.
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Abstract
Cocaine-dependent individuals show altered brain activation during decision making. It is unclear, however, whether these activation differences are related to relapse vulnerability. This study tested the hypothesis that brain-activation patterns during reinforcement learning are linked to relapse 1 year later in individuals entering treatment for cocaine dependence. Subjects performed a Paper-Scissors-Rock task during functional magnetic resonance imaging (fMRI). A year later, we examined whether subjects had remained abstinent (n=15) or relapsed (n=15). Although the groups did not differ on demographic characteristics, behavioral performance, or lifetime substance use, abstinent patients reported greater motivation to win than relapsed patients. The fMRI results indicated that compared with abstinent individuals, relapsed users exhibited lower activation in (1) bilateral inferior frontal gyrus and striatum during decision making more generally; and (2) bilateral middle frontal gyrus and anterior insula during reward contingency learning in particular. Moreover, whereas abstinent patients exhibited greater left middle frontal and striatal activation to wins than losses, relapsed users did not demonstrate modulation in these regions as a function of outcome valence. Thus, individuals at high risk for relapse relative to those who are able to abstain allocate fewer neural resources to action-outcome contingency formation and decision making, as well as having less motivation to win on a laboratory-based task.
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