ArticleNeuro-oncology2014
MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-Ras.
Open access · bronzeAbstract read
In one paragraph
Article in Neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- The significance of miR-124 in the diagnosis and prognosis of glioma: A systematic review.PloS one · 2024Pooled it
- Pooled it
- Astrocyte-derived miR-124 impairs glioma cell volume regulation and migration by reducing CaCellular and molecular life sciences : CMLS · 2026Article
- Multifaceted roles of miR‑124 in cancer: Molecular mechanisms and clinical prospects (Review).International journal of oncology · 2026Review
- G-protein coupled estrogen receptor 1Frontiers in endocrinology · 2026Article
- Microcargos with Megaeffects: A Literature Review of Immunomodulatory, Diagnostic, Prognostic, and Therapeutic Dimensions of Exosomal MicroRNAs in Glioblastoma Multiforme.Cellular and molecular neurobiology · 2025Review
- The role of abnormal epigenetic regulation of small GTPases in glioma (Review).International journal of oncology · 2025Review
- Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair.Cell death & disease · 2025Article
- LncRNA DNM1P35 sponges hsa-mir-326 to promote ovarian cancer progression.Scientific reports · 2024Article
- The RAS oncogene in brain tumors and the involvement of let-7 microRNA.Molecular biology reports · 2024Review
- Dysregulation of miRNA-mRNA expression in fetal growth restriction in a caloric restricted mouse model.Scientific reports · 2024Article
- Identification of circulating miRNA as early diagnostic molecular markers in malignant glioblastoma base on decision tree joint scoring algorithm.Journal of cancer research and clinical oncology · 2023Article
- The Significant Role of microRNAs in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application.Cellular and molecular neurobiology · 2023Review
- The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies.Cancer cell international · 2023Review
- Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia.Frontiers in neurology · 2023Article
- Recent advances in label-free optical, electrochemical, and electronic biosensors for glioma biomarkers.Biomicrofluidics · 2023Review
- circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets,International journal of molecular sciences · 2022Article
- miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases.Cellular and molecular neurobiology · 2022Review
- Neural stem cell‑derived exosomes transfer miR‑124‑3p into cells to inhibit glioma growth by targeting FLOT2.International journal of oncology · 2022Article
- MicroRNAs as prognostic markers and therapeutic targets in gliomas.Non-coding RNA research · 2022Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Zhumei ShiDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Qiudan ChenDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Chongyong LiDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Lin WangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Xu QianDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Chengfei JiangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Xue LiuDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Xiefeng WangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Hai LiDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Chunsheng KangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Tao JiangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Ling-Zhi LiuDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Yongping YouDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Ning LiuDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Bing-Hua JiangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (Z.S., X.W., Y.Y., N.L.); State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China (Z.S., Q.C., C.L., L.W., X.Q., C.J., X.L., B.-H.J.); Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (H.L.); Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China (C.K.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.-Z.L., B.-H.J.).
Capital Medical University · CNThomas Jefferson University · USTianjin Medical University General Hospital · CNBeijing Tian Tan Hospital · CNJiangsu Province Hospital · CNNanjing Medical University · CN
Funding
Molecular Mechanism of Arsenic CarcinogenesisR01ES020868 · NIEHS · UNIVERSITY OF IOWA · PI JIANG, BINGHUA · 2014 to 2018
$1.7MNIEHS NIH HHS R01ES020868
Abstract
backgroundGlioma is one of the most aggressive and lethal human brain tumors. Accumulating evidence shows that microRNAs play important roles in cancers, including glioma. Previous studies reported that miR-124 levels were downregulated in glioma specimens. Here, we further investigate the potential role of miR-124 in glioma.
methodsThe expression levels of miR-124 were detected in glioma specimens by quantitative reverse transcriptase PCR. The direct targets of miR-124 were identified by bioinformatics analysis and were further validated by immunoblotting and luciferase reporter assay. The effects of miR-124 on glioma cell proliferation and chemosensitivity to temozolomide were analyzed by Cell-Counting Kit 8 assay. Apoptosis was evaluated by fluorescence activated cell sorting analysis. A xenograft model was used to study the effect of miR-124 on tumor growth and angiogenesis.
resultsExpression levels of miR-124 were greatly downregulated in glioma specimens. related Ras viral oncogene homolog (R-Ras) and neuroblastoma Ras viral oncogene homolog (N-Ras) were identified as direct targets of miR-124. MiR-124 inhibited glioma cell growth, invasion, angiogenesis, and tumor growth and increased chemosensitivity to temozolomide treatment by negatively regulating the Ras family and its downstream signaling pathways: phosphatidylinositol-3 kinase/Akt and Raf/extracellular signal-regulated kinase 1/2. Furthermore, overexpression of R-Ras rescued the inhibitory effects of miR-124. Meanwhile, overexpression of R-Ras and N-Ras restored miR-124-inhibited vascular endothelial growth factor (VEGF) transcription activation. In clinical glioma specimens, protein levels of R-Ras and N-Ras were upregulated and inversely correlated with miR-124 expression levels.
conclusionsTaken together, these results revealed that miR-124 levels in tumor tissues are associated with glioma occurrence, angiogenesis, and chemoresistance and that miR-124 may be used as a new diagnostic marker and therapeutic target for glioma in the future.
Indexed as
Genes, rasNeovascularization, PathologicAnimalsApoptosisBrainBrain NeoplasmsCell Line, TumorCell ProliferationDacarbazineGliomaHumansMaleMiceMice, NudeMicroRNAsNeoplasm InvasivenessDacarbazineMicroRNAsMIRN124 microRNA, humanras ProteinsRRAS protein, humanTemozolomidecarcinogenesisgliomamiR-124N-RasR-Ras
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