ReviewIntegrative and comparative biology2014
Epigenetics and nutritional environmental signals.
Review in Integrative and comparative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Epigenetic and Neurogenomic Mechanisms Linking Physical Activity to Brain Plasticity and Cognitive Function.Genes · 2026Review
- Epigenetically Active Supplements and the Risk of Sports Injuries: Narrative Review from Molecular Mechanisms to Practical Implications.Nutrients · 2026Review
- Nutrition as a systems regulator of brain aging trajectories.Frontiers in molecular neuroscience · 2026Review
- Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights.Cell biology and toxicology · 2025Review
- Mini review: Studying epigenomic alterations can shed light on coping and adaptive abilities during heat stress in monogastric livestock.Frontiers in genetics · 2025Review
- Maternal Malnutrition and Elevated Disease Risk in Offspring.Nutrients · 2024Review
- Decoding the Foodome: Molecular Networks Connecting Diet and Health.Annual review of nutrition · 2024Review
- Cardiometabolic Effects of Postnatal High-Fat Diet Consumption in Offspring Exposed to Maternal Protein RestrictionFrontiers in physiology · 2022Review
- Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection.Frontiers in nutrition · 2022Review
- Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups.Acta cirurgica brasileira · 2021Article
- Epigenetic dynamics of the thermogenic gene program of adipocytes.The Biochemical journal · 2020Review
- A Susceptible Period of Photic Day-Night Rhythm Loss in Common Marmoset Social Behavior Development.Frontiers in behavioral neuroscience · 2020Article
- Genetic and epigenetic control of adipose development.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Influence of maternal nutrition and heat stress on bovine oocyte and embryo development.International journal of veterinary science and medicine · 2018Review
- DNA methylation and socioeconomic status in a Mexican-American birth cohort.Clinical epigenetics · 2018Article
- Nutrient supply alters transcriptome regulation in adipose tissue of pre-weaning Holstein calves.PloS one · 2018Article
- An endoparasitoid wasp influences host DNA methylation.Scientific reports · 2017Article
- Recent Findings in Alzheimer Disease and Nutrition Focusing on Epigenetics.Advances in nutrition (Bethesda, Md.) · 2016Review
- Nutritional Influence on Epigenetic Marks and Effect on Livestock Production.Frontiers in genetics · 2016Review
- Developmental Origins of Cardiometabolic Diseases: Role of the Maternal Diet.Frontiers in physiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
All terrestrial life is influenced by multi-directional flows of information about its environment, enabling malleable phenotypic change through signals, chemical processes, or various forms of energy that facilitate acclimatization. Billions of biological co-inhabitants of the earth, including all plants and animals, collectively make up a genetic/epigenetic ecosystem by which adaptation/survival (inputs and outputs) are highly interdependent on one another. As an ecosystem, the solar system, rotation of the planets, changes in sunlight, and gravitational pull influence cyclic epigenetic transitions and chromatin remodeling that constitute biological circadian rhythms controlling senescence. In humans, adverse environmental conditions such as poverty, stress, alcohol, malnutrition, exposure to pollutants generated from industrialization, man-made chemicals, and use of synthetic drugs can lead to maladaptive epigenetic-related illnesses with disease-specific genes being atypically activated or silenced. Nutrition and dietary practices are one of the largest facets in epigenetic-related metabolism, where specific "epi-nutrients" can stabilize the genome, given established roles in DNA methylation, histone modification, and chromatin remodeling. Moreover, food-based "epi-bioactive" constituents may reverse maladaptive epigenetic patterns, not only prior to conception and during fetal/early postnatal development but also through adulthood. In summary, in contrast to a static genomic DNA structure, epigenetic changes are potentially reversible, raising the hope for therapeutic and/or dietary interventions that can reverse deleterious epigenetic programing as a means to prevent or treat major illnesses.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.