ArticleGynecologic and obstetric investigation2014
Quantitative T2 changes and susceptibility-weighted magnetic resonance imaging in murine pregnancy.
Article in Gynecologic and obstetric investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- Diffusion-T2 correlated spectroscopy imaging to explore possible placental composition changes over gestation.BMC medical imaging · 2025Article
- In vivo T2 measurements of the fetal brain using single-shot fast spin echo sequences.Magnetic resonance in medicine · 2024Article
- Association of intraplacental oxygenation patterns on dual-contrast MRI with placental abnormality and fetal brain oxygenation.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2023Article
- Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment.MethodsX · 2022Article
- Placental MRI: Developing Accurate Quantitative Measures of Oxygenation.Topics in magnetic resonance imaging : TMRI · 2019Review
- Longitudinal Changes in Placental Magnetic Resonance Imaging Relaxation Parameter in Murine Pregnancy: Compartmental Analysis.Gynecologic and obstetric investigation · 2016Article
- Advanced MR imaging of the placenta: Exploring the in utero placenta-brain connection.Seminars in perinatology · 2015Review
- Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.PloS one · 2015Article
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11 authors at 2 institutions in 1 country.
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Abstract
objectiveTo evaluate gestational age-dependent changes in the T2 relaxation time in normal murine placentas in vivo. The role of susceptibility-weighted imaging (SWI) in visualization of the murine fetal anatomy was also elucidated.
methodsTimed-pregnant CD-1 mice at gestational day (GD) 12 and GD17 underwent magnetic resonance imaging. Multi-echo spin echo and SWI data were acquired. The placental T2 values on GD12 and GD17 were quantified. To account for the influence of systemic maternal physiological factors on placental perfusion, maternal muscle was used as a reference for T2 normalization. A linear mixed-effects model was used to fit the normalized T2 values, and the significance of the coefficients was tested. Fetal SWI images were processed and reviewed for venous vasculature and skeletal structures.
resultsThe average placental T2 value decreased significantly on GD17 (40.17 ± 4.10 ms) compared to the value on GD12 (55.78 ± 8.13 ms). The difference in normalized T2 values also remained significant (p = 0.001). Using SWI, major fetal venous structures like the cardinal vein, the subcardinal vein, and the portal vein were visualized on GD12. In addition, fetal skeletal structures could also be discerned on GD17.
conclusionThe T2 value of a normal murine placenta decreases with advancing gestation. SWI provided clear visualization of the fetal venous vasculature and bony structures. © 2014 S. Karger AG, Basel.
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