Evidence map›Paper›PMID 24861553›Full record

SynthesisHuman molecular genetics2014

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

Wanqing Wen, Wei Zheng, Yukinori Okada, Fumihiko Takeuchi, Yasuharu Tabara, Joo-Yeon Hwang, Rajkumar Dorajoo, Huaixing Li, Fuu-Jen Tsai, Xiaobo Yang and 99 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 12 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 12 syntheses or guidelines pooled it, 203 citations in OpenAlex.

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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

109 authors at 20 institutions in 10 countries.

Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Yukinori OkadaLaboratory for Statistical Analysis, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Joo-Yeon HwangCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
Huaixing LiKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
Fuu-Jen TsaiSchool of Chinese Medicine, Department of Medical Genetics, Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
Xiaobo YangDepartment of Occupational Health and Environmental Health, School of Public Health, Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Meian HeDepartment of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Yi ZhangState Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Hypertension, Shanghai, China.
Jun LiangDepartment of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu 221009, China.
Xiuqing GuoLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
Wayne Huey-Herng SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, National Defense Medical Center, College of Medicine, Taipei, Taiwan, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Ryan DelahantyDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Xingyi GuoDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Michiaki KuboLaboratory for Genotyping Development.
Ken YamamotoDepartment of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Takayoshi OhkuboDepartment of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan, Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
Min Jin GoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Jian Jun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Wei GanKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
Ching-Chu ChenSchool of Chinese Medicine, Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan.
Yong GaoCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, College of General Practice, Guangxi Medical University, Nanning, Guangxi, China.
Shengxu LiDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Nanette R LeeUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu, Philippines.
Chen WuState Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xueya ZhouBioinformatics Division, Tsinghua National Laboratory of Information Science and Technology, Beijing, China.
Huaidong SongState Key Laboratory of Medical Genomics, Ruijin Hospital, Molecular Medical Center, Shanghai Institute of Endocrinology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie YaoLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Tatsuhiko TsunodaLaboratory for Medical Science Mathematics.
Koichi AkiyamaDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Naoyuki TakashimaDepartment of Health Science, Shiga University of Medical Science, Otsu, Japan.
Yoon Shin ChoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Department of Biomedical Science, Hallym University, Gangwon-do, Republic of Korea.
Rick Th OngGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore.
Ling LuKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
Chien-Hsiun ChenSchool of Chinese Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Aihua TanCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
Lixuan GuiDepartment of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Matthew AllisonDepartment of Family and Preventive Medicine.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Social Work, Tunghai University, Taichung, Taiwan.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Minoru IsomuraDepartment of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.
Satoshi UmemuraDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
Young Jin KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Mark SeielstadInstitute of Human Genetics, University of California, San Francisco, USA.
James HixsonHuman Genetics Center, University of Texas School of Public Health, Houston, TX, USA.
Yong-Bing XiangShanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Masato IsonoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Bong-Jo KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Xueling SimCentre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore.
Wei LuShanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Toru NabikaDepartment of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.
Juyoung LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Wei-Yen LimSaw Swee Hock School of Public Health.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Dae-Hee KangDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
I-Chien WuInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jyh-Ming Jimmy JuangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jiajun ShiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Bo Youl ChoiDepartment of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.
Frank HuDepartment of Epidemiology, Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA.
Mi Kyung KimDepartment of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Wei Yen LimSaw Swee Hock School of Public Health.
Tzung-Dao WangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Jeannette LeeSaw Swee Hock School of Public Health.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Young-Hoon LeeDepartment of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Republic of Korea.
Terri L YoungDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA, Division of Neuroscience, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.
Dong Hoon ShinDepartment of Preventive Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea.
Byung-Yeol ChunDepartment of Preventive Medicine, School of Medicine, and Health Promotion Research Center, Kyungpook National University, Daegu, Republic of Korea.
Myeong-Chan ChoNational Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Bok-Ghee HanCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Chii-Min HwuSchool of Medicine, National Yang-Ming University, Taipei, Taiwan, Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Xiaofei YanLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
Eric KimLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
Jane Z KuoNShiley Eye Center, Department of Ophthalmology, University of California at San Diego, La Jolla, CA, USA.
Soonil KwonLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
Kent D TaylorLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
Yii-Der I ChenLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
Jerome I RotterLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
Lu QiDepartment of Nutrition, Harvard University School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
Dingliang ZhuState Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Hypertension, Shanghai, China.
Tangchun WuDepartment of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Dongfeng GuDepartment of Evidence Based Medicine, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and National Center for Cardiovascular Diseases, Beijing, China.
Zengnan MoCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Jer-Yuarn WuSchool of Chinese Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
Tetsuro MikiDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan.
E Shyong TaiSaw Swee Hock School of Public Health, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, and National University Health System, Singapore, Singapore Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.
Jong-Young LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA, xiao-ou.shu@vanderbilt.edu.
Toshihiro TanakaDepartment of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.
Korea National Institute of Health · KRVanderbilt University · USThe Lundquist Institute · USGuangxi Medical University · CNNational Center for Global Health and Medicine · JPHarbor–UCLA Medical Center · USHuazhong University of Science and Technology · CNShanghai Institutes for Biological Sciences · CNUniversity of North Carolina at Chapel Hill · USChinese Academy of Medical Sciences & Peking Union Medical College · CNGenome Institute of Singapore · SGHanyang University · KRHarvard University · USInstitute of Biomedical Sciences, Academia Sinica · TWKyushu University · JPNational Health Research Institutes · TWNational Taiwan University Hospital · TWNational University of Singapore · SGShiga University of Medical Science · JPShimane University · JP

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI LOWELL, BRADFORD B · 1992 to 2021
$25.0M
Tulane Building Interdisciplinary Research Careers in Women's Health (BIRCWH)K12HD043451 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI KROUSEL-WOOD, MARIE · 2002 to 2023
$9.9M
Genetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6M
Cohort Study of Cancer inhibitory Factors in MenR01CA082729 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2011
$6.3M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Common Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
FIC NIH HHS R01 TW005596FIC NIH HHS R01 TW008288FIC NIH HHS TW008288FIC NIH HHS TW05596NCATS NIH HHS UL1 TR000124NCI NIH HHS R01 CA064277NCI NIH HHS R01CA064277NCI NIH HHS R01 CA082729NCI NIH HHS R01CA082729NCI NIH HHS R01 CA092585NCI NIH HHS R01CA092585NCI NIH HHS R01 CA122364NCI NIH HHS R01CA122364NCI NIH HHS R01 CA124558NCI NIH HHS R01CA124558NCI NIH HHS R01 CA148667NCI NIH HHS R01CA148667NCI NIH HHS R37 CA070867NCI NIH HHS R37CA070867NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NCRR NIH HHS P20 RR020649NCRR NIH HHS RR-024156NCRR NIH HHS RR20649NCRR NIH HHS UL1 RR024156NHLBI NIH HHS HL071981NHLBI NIH HHS HL085144NHLBI NIH HHS HL087647NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01HL087263NHLBI NIH HHS R01 HL087647NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01HL090682NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01HL072507NICHD NIH HHS K12 HD043451NIDDK NIH HHS DK078150NIDDK NIH HHS DK078616NIDDK NIH HHS DK091718NIDDK NIH HHS DK46200NIDDK NIH HHS DK56350NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK078150NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK091718NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616NIEHS NIH HHS ES10126NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

Indexed as

5'-NucleotidaseAldehyde DehydrogenaseAldehyde Dehydrogenase, MitochondrialAsia, EasternAsian PeopleBlood ProteinsBody Mass IndexCardiac MyosinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGlycoproteinsHumansKCNQ1 Potassium ChannelMaleMyosin Light Chains5'-NucleotidaseAldehyde DehydrogenaseAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanBlood ProteinsCardiac MyosinsGlycoproteinsITIH4 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, humanmyosin light chain 2Myosin Light ChainsNT5C2 protein, humanProteinase Inhibitory Proteins, Secretory

Identifiers

PMID24861553
PMCPMC4168820
OpenAlexW2148704941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.