ArticleExperimental neurology2014
Neurologic impairment following closed head injury predicts post-traumatic neurogenesis.
Article in Experimental neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats.Journal of neurotrauma · 2019Pooled it
- Sexually Dimorphic Responses Reveal Multifaceted Benefits of Glibenclamide in Traumatic Brain Injury.Journal of neurotrauma · 2025Article
- Chronic Stress in Early Development and Effects on Traumatic Brain Injury Outcome.Advances in neurobiology · 2024Review
- Article
- Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury.Frontiers in neuroscience · 2021Article
- Olfactory Dysfunction in Traumatic Brain Injury: the Role of Neurogenesis.Current allergy and asthma reports · 2020Review
- Neuroinflammatory mechanisms of post-traumatic epilepsy.Journal of neuroinflammation · 2020Review
- Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.Journal of neurotrauma · 2019Article
- Ketamine Alters Hippocampal Cell Proliferation and Improves Learning in Mice after Traumatic Brain Injury.Anesthesiology · 2018Article
- IKK2/NF-κB signaling protects neurons after traumatic brain injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- The Potential of Stem Cells in Treatment of Traumatic Brain Injury.Current neurology and neuroscience reports · 2018Review
- Altered Hippocampal Neurogenesis during the First 7 Days after a Fluid Percussion Traumatic Brain Injury.Cell transplantation · 2017Article
- Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury.Experimental neurology · 2016Review
- Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury(1,2,3).eNeuro · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In the mammalian hippocampus, neurogenesis persists into adulthood, and increased generation of newborn neurons could be of clinical benefit following concussive head injuries. Post-traumatic neurogenesis has been well documented using "open" traumatic brain injury (TBI) models in rodents; however, human TBI most commonly involves closed head injury. Here we used a closed head injury (CHI) model to examine post-traumatic hippocampal neurogenesis in mice. All mice were subjected to the same CHI protocol, and a gross-motor based injury severity score was used to characterize neurologic impairment 1h after the injury. When analyzed 2weeks later, post-traumatic neurogenesis was significantly increased only in mice with a high degree of transient neurologic impairment immediately after injury. This increase was associated with an early increase in c-fos activity, and subsequent reactive astrocytosis and microglial activation in the dentate gyrus. Our results demonstrate that the initial degree of neurologic impairment after closed head injury predicts the induction of secondary physiologic and pathophysiologic processes, and that animals with severe neurologic impairment early after injury manifest an increase in post-traumatic neurogenesis in the absence of gross anatomic pathology.
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Registered trials
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