ArticleJournal of cardiac surgery2014
Myocardial protection using del nido cardioplegia solution in adult reoperative aortic valve surgery.
Article in Journal of cardiac surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 114 citations in OpenAlex.
- Protective Efficacy on Adult Ischemic Myocardium under Bypass: Del Nido vs. St. Thomas Blood Cardioplegia.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2023Trial
- The use of del Nido cardioplegia in adult cardiac surgery: A prospective randomized trial.The Journal of thoracic and cardiovascular surgery · 2018Trial
- Cardioplegia strategy and perioperative blood transfusion in isolated coronary artery bypass surgery: a propensity-weighted analysis.Journal of cardiothoracic surgery · 2026Article
- Efficacy of Single-Dose Del Nido Cardioplegia Beyond 90 Minutes in Adult Cardiac Surgery.Journal of clinical medicine · 2025Article
- Outcomes of Del Nido and hyperkalemic blood cardioplegia in adult cardiac surgery with prolonged aortic cross-clamp times★.The journal of extra-corporeal technology · 2024Article
- Del Nido vs. Cold Blood Cardioplegia for High-Risk Isolated Coronary Artery Bypass Grafting in Patients with Reduced Ventricular Function.Brazilian journal of cardiovascular surgery · 2024Article
- Whole Blood del Nido versus Cold Blood Microplegia in Adult Cardiac Surgery: A Propensity-Matched Analysis.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024Article
- Del Nido cardioplegia versus blood cardioplegia in coronary artery bypass grafting.Indian journal of thoracic and cardiovascular surgery · 2024Article
- Del Nido cardioplegia or potassium induces Nrf2 and protects cardiomyocytes against oxidative stress.American journal of physiology. Cell physiology · 2023Article
- Outcomes of del Nido cardioplegia after surgical aortic valve replacement and coronary artery bypass grafting.General thoracic and cardiovascular surgery · 2023Article
- A novel dosing strategy of del Nido cardioplegia in aortic surgery.JTCVS open · 2022Article
- Use of del Nido Cardioplegia for Adult Heart Surgery: How Long Is Not Too Long?The journal of extra-corporeal technology · 2020Article
- Comparison of the operative and postoperative effects of del Nido and blood cardioplegia solutions in cardiopulmonary bypass surgery.Brazilian journal of cardiovascular surgery · 2020Article
- Evaluating Changes in del Nido Cardioplegia Practices in Adult Cardiac Surgery.The journal of extra-corporeal technology · 2020Article
- del Nido cardioplegia in surgery for aortic root disease: a historically controlled study.Journal of thoracic disease · 2020Article
- Del Nido Cardioplegia Versus Cold Blood Cardioplegia in Adult Cardiac Surgery: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2020Article
- Transitioning to Del Nido cardioplegia for all-comers: the next switching gear?BMC cardiovascular disorders · 2020Observational
- Effect of single-dose crystalloid cardioplegic agent compared to bloody cardioplegic agent in cardiac surgery in children with Tetralogy of Fallot.ARYA atherosclerosis · 2020Article
- Lactated Ringer's as a Base Solution for del Nido Cardioplegia.The journal of extra-corporeal technology · 2019Observational
- Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice.Biology of sex differences · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsThe immediate postischemic period is marked by elevated intracellular calcium levels, which can lead to irreversible myocyte injury. Del Nido cardioplegia was developed for use in the pediatric population to address the inability of immature myocardium to tolerate high levels of intracellular calcium following cardiac surgery. Our aim in this study is to determine if this solution can be used safely and effectively in an adult, reoperative population.
methodsAll patients undergoing isolated reoperative aortic valve replacement at our institution from 2010 to 2012 were retrospectively reviewed. Demographics, comorbidities, operative variables, postoperative complications, and patient outcomes were collected. Patients were divided into two groups based on cardioplegia strategy used: whole blood cardioplegia (WB, n = 61) and del Nido cardioplegia (DN, n = 52).
resultsMean age in the study was 73.4 ± 14.3 years and 86 patients were male (76.1%). Eighty-four patients had undergone prior coronary artery bypass graft (CABG) (74.3%). Patients in the DN group required significantly lower total volume of cardioplegia (1147.6 ± 447.2 mL DN vs. 1985.4 ± 691.1 mL WB, p < 0.001) and retrograde cardioplegia dose (279.3 ± 445.1 mL DN vs. 1341.2 ± 690.8 mL WB, p < 0.001). There were no differences in cross-clamp time, bypass time, postoperative complication rate, or patient outcomes between groups.
conclusionsDel Nido cardioplegia use in an adult, reoperative aortic valve population offers equivalent postoperative outcomes when compared with whole blood cardioplegia. In addition, use of del Nido solution requires lower total and retrograde cardioplegia volumes in order to achieve adequate myocardial protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.