Evidence map›Paper›PMID 24861055›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2014

Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infection.

Fuqin Zhang, Xiaohui Zhou, Joanna R DiSpirito, Chuan Wang, Ying Wang, Hao Shen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 95 citations in OpenAlex.

  1. Trial
  2. Epigenetic insights and innovations for overcoming barriers in CAR-T cell therapy for cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Regulation of CD8Cellular & molecular immunology · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Epigenetic strategies to boost CAR T cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Fuqin Zhang1] Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China [2] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xiaohui Zhou1] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA [2] Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Joanna R DiSpiritoDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Chuan Wang1] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA [2] Department of Public Health Laboratory Sciences, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China.
Ying WangShanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Hao Shen1] Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China [2] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USShanghai Jiao Tong University · CNShanghai Public Health Clinical Center · CN

Funding

Molecular basis of defective CD8 T cells during chronic viral infectionR21AI079724 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHEN, HAO · 2009 to 2010
$433k
NIAID NIH HHS R21 AI079724
6 · The paper itself

Abstract

Functional exhaustion of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T cell dysfunction are not well understood. Epigenetics plays an important role in the control of T cell development, differentiation, and function. To examine if epigenetics also plays a role in T cell exhaustion, we analyzed chromatin remodeling in CD8(+) T cells from mice with chronic lymphocytic choriomeningitis virus infection. We observed downregulation of diacetylated histone H3 in both virus-specific and total CD8(+) T cells, and functional defects not only in virus-specific CD8(+) T cells but also within the total CD8(+) T cell population. In vitro treatment of these exhausted CD8(+) T cells with histone deacetylase inhibitors restored diacetylated histone H3 levels, and improved their immune functions. Upon adoptive transfer, these treated CD8(+) T cells developed into functional memory T cells in vivo that enhanced protective immunity. These results define a role of epigenetics in T cell exhaustion and suggest epigenetic manipulation as a novel molecular therapy to restore immune functions.

Indexed as

Epigenesis, GeneticAdoptive TransferAnimalsArenaviridae InfectionsCD8-Positive T-LymphocytesChromatin Assembly and DisassemblyEnzyme InhibitorsFemaleHistonesLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLEnzyme InhibitorsHistones

Identifiers

PMID24861055
PMCPMC4435497
OpenAlexW1998458019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.