SynthesisBioMed research international2014
Association between two common polymorphisms and risk of hepatocellular carcinoma: evidence from an updated meta-analysis.
Synthesis in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- MicroRNA polymorphism: A target for diagnosis and prognosis of hepatocellular carcinoma?Oncology letters · 2021Review
- Polymorphisms in miRNAs Gene (146a, 149, 196a) and Susceptibility to ARV-associated Hepatotoxicity.Current genomics · 2019Article
- MicroRNA-196a2 Biomarker and Targetome Network Analysis in Solid Tumors.Molecular diagnosis & therapy · 2016Article
- Common functional polymorphism within miR-146a and miR-196a-2 as susceptibility loci for hepatocellular carcinoma: An updated meta-analysis.Meta gene · 2016Article
- The occurrence of cervical cancer in Uygur women in Xinjiang Uygur Autonomous Region is correlated to microRNA-146a and ethnic factor.International journal of clinical and experimental pathology · 2015Article
- Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan.Cancer genomics & proteomicsArticle
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Authors and funding
6 authors.
Funding
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Abstract
backgroundRecent studies suggested that two common polymorphisms, miR-146a G>C and miR-196a2 C>T, may be associated with individual susceptibility to hepatocellular carcinoma (HCC). However, the results remain conflicting rather than conclusive. Object. The aim of this study was to assess the association between miR-146a G>C and miR-196a2 C>T polymorphisms and the risk of HCC.
methodsA meta-analysis of 17 studies (10938 cases and 11967 controls) was performed. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association.
resultsFor miR-146a G>C, the variant genotypes were associated with a decreased risk of HCC (CC versus GG: OR = 0.780 and 95% CI 0.700-0.869; GC/CC versus GG: OR = 0.865 and 95% CI 0.787-0.952; CC versus GC/GG: OR = 0.835 and 95% CI 0.774-0.901). For miR-196a2 C>T, significant association was also observed (TT versus CC: OR = 0.783, 95% CI: 0.649-0.943, and P = 0.010; CT versus CC: OR = 0.831, 95% CI 0.714-0.967, and P = 0.017; CT/TT versus CC: OR = 0.817, 95% CI 0.703-0.949, and P = 0.008).
conclusionThe two common polymorphisms miR-146a G>C and miR-196a2 C>T were associated with decreased HCC susceptibility, especially in Asian population.
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