Evidence map›Paper›PMID 24860795›Full record

ArticleJournal of diabetes and metabolic disorders2014

Predictive factors of diabetic complications: a possible link between family history of diabetes and diabetic retinopathy.

Zhila Maghbooli, Parvin Pasalar, Abbasali Keshtkar, Farshad Farzadfar, Bagher Larijani

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Article in Journal of diabetes and metabolic disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhila MaghbooliEndocrinology and Metabolism Clinical Sciences Institute of Tehran University of medical sciences, Postal address; EMRI, 5th floor, Shariati Hospital, North Karegar avenue, P.O Box: 1411413137, Tehran, Iran.
Parvin PasalarBiochem, Department Faculty of Medicine Tehran University of medical sciences, Postal address; EMRI, 5th floor, Shariati Hospital, North Karegar avenue, P.O Box: 1411413137, Tehran, Iran.
Abbasali KeshtkarEndocrinology and Metabolism Clinical Sciences Institute of Tehran University of medical sciences, Postal address; EMRI, 5th floor, Shariati Hospital, North Karegar avenue, P.O Box: 1411413137, Tehran, Iran.
Farshad FarzadfarEndocrinology and Metabolism Population Sciences Institute of Tehran University of medical sciences, 4th floor, No. 4, Ostad Nejatollahi St, Enqelab Ave, 1599666615 Tehran, Iran.
Bagher LarijaniEndocrinology and Metabolism Clinical Sciences Institute of Tehran University of medical sciences, Postal address; EMRI, 5th floor, Shariati Hospital, North Karegar avenue, P.O Box: 1411413137, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was assessment of predictive factors of diabetic retinopathy.

methodsA cross-sectional study was designed by recruiting 1228 type 2 diabetic patients from a diabetes referral clinic over a six-month period (from July to December, 2012). Diabetes risk factors, complications, laboratory results have been recorded.

resultsOf the 1228 diabetic patients (54% women, mean age 58.48 ± 9.94 years), prevalence of diabetes retinopathy was 26.6%. There were significant associations between retinopathy and family history of diabetes (p = 0.04), hypertension (p = 0.0001), diabetic duration (p = 0.0001), poor glycemic control (p = 0.0001) and age of onset of diabetes (p = 0.0001). However, no significant associations were found between retinopathy with dyslipidemia and obesity. In logistic regression model, poor glycemic control (p = 0.014), hypertension (p = 0.0001), duration of diabetes (p = 0.0001) and family history of diabetes (p = 0.012) independently predicted retinopathy after adjustment for age and sex.

conclusionsDiabetic complications are resulting from an interaction from genes and environmental factors. A family history of diabetes is pointing toward a possible genetic and epigenetic basis for diabetic retinopathy. Our findings suggest the role of epigenetic modifications and metabolic memory in diabetic retinopathy in subjects with family history of diabetes.

Indexed as

Diabetic retinopathyEpigeneticFamily history of diabetes

Identifiers

PMID24860795
PMCPMC4031909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.