Evidence map›Paper›PMID 24860722›Full record

ReviewCurrent environmental health reports2014

The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review.

Christina R Tyler, Andrea M Allan

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current environmental health reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 2 pooled it
26.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 2 syntheses or guidelines pooled it, 529 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christina R TylerDepartment of Neuroscience, University of New Mexico School of Medicine, Albuquerque, NM USA.
Andrea M AllanDepartment of Neuroscience, University of New Mexico School of Medicine, Albuquerque, NM USA.
University of New Mexico · US

Funding

Prenatal arsenic exposure alters transcriptional, post-transcriptional and post-translational programming of the glucocorticoid system in a sexually dimorphic mannerR01ES019583 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ALLAN, ANDREA M · 2011 to 2021
$3.3M
The epigenetic link between environmental exposure and adult onset depressionF31MH101984 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI TYLER, CHRISTINA RENE · 2013 to 2014
$43k
NIEHS NIH HHS R01 ES019583NIMH NIH HHS F31 MH101984
6 · The paper itself

Abstract

Arsenic toxicity is a worldwide health concern as several millions of people are exposed to this toxicant via drinking water, and exposure affects almost every organ system in the body including the brain. Recent studies have shown that even low concentrations of arsenic impair neurological function, particularly in children. This review will focus on the current epidemiological evidence of arsenic neurotoxicity in children and adults, with emphasis on cognitive dysfunction, including learning and memory deficits and mood disorders. We provide a cohesive synthesis of the animal studies that have focused on neural mechanisms of dysfunction after arsenic exposure including altered epigenetics; hippocampal function; glucocorticoid and hypothalamus-pituitary-adrenal axis (HPA) pathway signaling; glutamatergic, cholinergic and monoaminergic signaling; adult neurogenesis; and increased Alzheimer's-associated pathologies. Finally, we briefly discuss new studies focusing on therapeutic strategies to combat arsenic toxicity including the use of selenium and zinc.

Indexed as

AdultAlzheimer’s diseaseAnxietyArsenateArsenicArseniteChildrenCholinergicCognitionCortisolDepressionDevelopmentDNA methylationEpigeneticsExposureGlucocorticoid receptorGlutamatergicHistone modificationsHPAIQLeadMonoaminergicMood disordersNeurogenesisNeurological deficitsNeurotoxicityTeratogen

Identifiers

PMID24860722
PMCPMC4026128
OpenAlexW1984196841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.