ArticleFrontiers in plant science2014
Role of the VirA histidine autokinase of Agrobacterium tumefaciens in the initial steps of pathogenesis.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The Ti Plasmid-Encoded VirJ Functions as a Lysyl-Phosphatidylglycerol Hydrolase in Agrobacterium tumefaciens.Molecular microbiology · 2026Article
- Agrobacterium-mediated gene transfer: recent advancements and layered immunity in plants.Planta · 2022Review
- Functional Annotation of Hypothetical Proteins From theBioinformatics and biology insights · 2022Article
- Mechanistic Analysis of the VirA Sensor Kinase inFrontiers in microbiology · 2022Article
- Bacterial two-component systems as sensors for synthetic biology applications.Current opinion in systems biology · 2021Article
- Improvement of a Genetic Transformation System and Preliminary Study on the Function ofInternational journal of molecular sciences · 2020Article
- The MexE/MexF/AmeC Efflux Pump of Agrobacterium tumefaciens and Its Role in Ti Plasmid Virulence Gene Expression.Journal of bacteriology · 2020Article
- Mapping Reaction-Diffusion Networks at the Plant Wound Site With Pathogens.Frontiers in plant science · 2020Article
- A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues.Nature communications · 2016Article
- Adaptation of the Agrobacterium tumefaciens VirG response regulator to activate transcription in plants.Plant molecular biology · 2016Article
- Plant phenolic compounds and oxidative stress: integrated signals in fungal-plant interactions.Current genetics · 2015Review
- Signal transduction in histidine kinases: insights from new structures.Structure (London, England : 1993) · 2015Review
- The Receiver of the Agrobacterium tumefaciens VirA Histidine Kinase Forms a Stable Interaction with VirG to Activate Virulence Gene Expression.Frontiers in microbiology · 2015Article
- Article
- Editorial: "Agrobacterium biology and its application to transgenic plant production".Frontiers in plant science · 2015Article
- Cell fate regulation governed by a repurposed bacterial histidine kinase.PLoS biology · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Histidine kinases serve as critical environmental sensing modules, and despite their designation as simple two-component modules, their functional roles are remarkably diverse. In Agrobacterium tumefaciens pathogenesis, VirA serves with VirG as the initiating sensor/transcriptional activator for inter-kingdom gene transfer and transformation of higher plants. Through responses to three separate signal inputs, low pH, sugars, and phenols, A. tumefaciens commits to pathogenesis in virtually all flowering plants. However, how these three signals are integrated to regulate the response and why these signals might be diagnostic for susceptible cells across such a broad host-range remains poorly understood. Using a homology model of the VirA linker region, we provide evidence for coordinated long-range transmission of inputs perceived both outside and inside the cell through the creation of targeted VirA truncations. Further, our evidence is consistent with signal inputs weakening associations between VirA domains to position the active site histidine for phosphate transfer. This mechanism requires long-range regulation of inter-domain stability and the transmission of input signals through a common integrating domain for VirA signal transduction.
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