ArticleFrontiers in plant science2014
Comparative phylogenomics of the CBL-CIPK calcium-decoding network in the moss Physcomitrella, Arabidopsis, and other green lineages.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 90 citations in OpenAlex.
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- Evolution and functional characterization of Populus salt stress-responsive calcineurin B-like protein-interacting protein kinases.Plant cell reports · 2024Article
- Evolution and subfunctionalization of CIPK6 homologous genes in regulating cotton drought resistance.Nature communications · 2024Article
- Understanding the salt overly sensitive pathway in Prunus: Identification and characterization of NHX, CIPK, and CBL genes.The plant genome · 2024Article
- The putative myristoylome of Physcomitrium patens reveals conserved features of myristoylation in basal land plants.Plant cell reports · 2023Article
- CIPK-B is essential for salt stress signalling in Marchantia polymorpha.The New phytologist · 2023Article
- Functional identification of the calcineurin B-like protein PavCBL4 in modulating salt tolerance in sweet cherry.Frontiers in plant science · 2023Article
- Cold Tolerance ofCurrent issues in molecular biology · 2022Article
- The Peach (Plants (Basel, Switzerland) · 2022Article
- Evolution of the CBL and CIPK gene families in Medicago: genome-wide characterization, pervasive duplication, and expression pattern under salt and drought stress.BMC plant biology · 2022Article
- Insight into the CBL and CIPK gene families in pecan (Carya illinoinensis): identification, evolution and expression patterns in drought response.BMC plant biology · 2022Article
- Stress-associated developmental reprogramming in moss protonemata by synthetic activation of the common symbiosis pathway.iScience · 2022Article
- The Calcium Sensor Calcineurin B-Like Proteins -Calcineurin B-Like Interacting Protein Kinases Is Involved in Leaf Development and Stress Responses Related to Latex Flow inFrontiers in plant science · 2022Article
- A Comprehensive Analysis of Calmodulin-Like Proteins ofFrontiers in plant science · 2022Article
- Genome-wide identification of calcineurin B-like protein-interacting protein kinase gene family reveals members participating in abiotic stress in the ornamental woody plantFrontiers in plant science · 2022Article
- The Same against Many: AtCML8, a CaInternational journal of molecular sciences · 2021Article
- Identification and Characterization of Abiotic Stress Responsive CBL-CIPK Family Genes inInternational journal of molecular sciences · 2021Article
- Protein kinase PpCIPK1 modulates plant salt tolerance in Physcomitrella patens.Plant molecular biology · 2021Article
- Molecular Interaction and Evolution of Jasmonate Signaling With Transport and Detoxification of Heavy Metals and Metalloids in Plants.Frontiers in plant science · 2021Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Land plants have evolved a host of anatomical and molecular adaptations for terrestrial growth. Many of these adaptations are believed to be elaborations of features that were present in their algal-like progenitors. In the model plant Arabidopsis, 10 Calcineurin B-Like proteins (CBLs) function as calcium sensors and modulate the activity of 26 CBL-Interacting Protein Kinases (CIPKs). The CBL-CIPK network coordinates environmental responses and helps maintain proper ion balances, especially during abiotic stress. We identified and analyzed CBL and CIPK homologs in green lineages, including CBLs and CIPKs from charophyte green algae, the closest living relatives of land plants. Phylogenomic evidence suggests that the network expanded from a small module, likely a single CBL-CIPK pair, present in the ancestor of modern plants and algae. Extreme conservation of the NAF motif, which mediates CBL-CIPK physical interactions, among all identified CIPKs supports the interpretation of CBL and CIPK homologs in green algae and early diverging land plants as functionally linked network components. We identified the full complement of CBL and CIPK loci in the genome of Physcomitrella, a model moss. These analyses demonstrate the strong effects of a recent moss whole genome duplication: CBL and CIPK loci appear in cognate pairs, some of which appear to be pseudogenes, with high sequence similarity. We cloned all full-length transcripts from these loci and performed yeast two-hybrid analyses to demonstrate CBL-CIPK interactions and identify specific connections within the network. Using phylogenomics, we have identified three ancient types of CBLs that are discernible by N-terminal localization motifs and a "green algal-type" clade of CIPKs with members from Physcomitrella and Arabidopsis.
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