ReviewFrontiers in immunology2014
Control of acute dengue virus infection by natural killer cells.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review.Health science reports · 2026Article
- Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?Cell communication and signaling : CCS · 2023Review
- NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice.JCI insight · 2022Article
- Article
- Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patients.Experimental hematology & oncology · 2021Article
- Review
- HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response.Frontiers in cellular and infection microbiology · 2019Article
- Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model.Nature communications · 2018Article
- Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses.Computational and mathematical methods in medicine · 2018Article
- Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection.Cellular & molecular immunology · 2016Article
- Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells.Clinical and experimental immunology · 2016Article
- Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients.PLoS neglected tropical diseases · 2016Article
- Roles of natural killer cells in antiviral immunity.Current opinion in virology · 2016Review
- Article
- Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections.Journal of the Royal Society, Interface · 2015Article
- Protective immune responses to dengue virus infection and vaccines: perspectives from the field to the bench.Frontiers in immunology · 2015Article
- Regulation and Function of NK and T Cells During Dengue Virus Infection and Vaccination.Advances in experimental medicine and biologyReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue fever is the most important arthropod-borne viral disease worldwide, affecting 50-100 million individuals annually. The clinical picture associated with acute dengue virus (DENV) infections ranges from classical febrile illness to life-threatening disease. The innate immunity is the first line of defense in the control of viral replication. This review will examine the particular role of natural killer (NK) cells in DENV infection. Over recent years, our understanding of the interplay between NK cells and viral pathogenesis has improved significantly. NK cells express an array of inhibitory and activating receptors that enable them to detect infected targets while sparing normal cells, and to recruit adaptive immune cells. To date, the exact mechanism by which NK cells may contribute to the control of DENV infection remains elusive. Importantly, DENV has acquired mechanisms to evade NK cell responses, further underlining the relevance of these cells in pathophysiology. Hence, understanding how NK cells affect the outcome of DENV infection could benefit the management of this acute disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.