ReviewFrontiers in microbiology2014
Retrospective and prospective perspectives on zoonotic brucellosis.
Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
164 citing papers in PubMed, 6 syntheses or guidelines pooled it, 302 citations in OpenAlex.
- Prevalence, Associated Factors, and Temporal Trends of Brucella Detection Across Human and Animal Hosts in Bangladesh: A 25-Year Meta-Analysis.Veterinary medicine and science · 2026Pooled it
- A Systematic Review and Meta-Analysis on the Prevalence of Brucella melitensis in Sheep and Goat.Veterinary medicine and science · 2025Pooled it
- What do we really know about brucellosis diagnosis in livestock worldwide? A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Human and animal brucellosis and risk factors for human infection in Ethiopia: a systematic review and meta-analysis (2015-2024).BMC public health · 2024Pooled it
- Evaluation of immune responses toFrontiers in veterinary science · 2022Pooled it
- Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis.PLoS neglected tropical diseases · 2016Pooled it
- Prevalence and speciation of brucellosis in febrile patients from a pastoralist community of Tanzania.Scientific reports · 2020Trial
- Influence of heme and pH on the oligomeric states of Brucella melitensis bacterioferritin.Acta crystallographica. Section D, Structural biology · 2026Article
- Comparison of Various Rose Bengal Plate Tests, Serum Tube Agglutination Tests, and Enzyme-Linked Immunosorbent Assays Used in Brucellosis Serosurveillance in Sheep, Bovines, and Spotted Deer.Veterinary sciences · 2026Article
- Single Radial Immunodiffusion (SRID) Assay for Quantitative Determination of Recombinant SOD Protein in a Brucellosis Vaccine Candidate: Method Development and Validation.Methods and protocols · 2026Article
- Pathogenesis of Brucella abortus and Brucella melitensis in bovine and ovine-derived trophoblasts and macrophages and impaired intracellular trafficking of the Rev1 vaccine strain.Veterinary research · 2026Article
- RETRACTED: Brucella melitensis infection with osteoarticular involvement: First reported cases in Colombia. https://doi.org/10.7705/biomedica.8614Biomedica : revista del Instituto Nacional de Salud · 2026Article
- Impact of inactivation methods on biosafety and antigen reactivity of Brucella melitensis from the perspective of Astral-DIA proteomics based on antibody immunoprecipitation mass spectrometry.PLoS neglected tropical diseases · 2026Article
- Recognition of Brucella abortus drives M2 like polarization and impaired antigen presentation in monocyte derived macrophages.Scientific reports · 2026Article
- Myeloid-derived suppressor cells and their subsets serve as potential biomarkers for the progression of brucellosis.Frontiers in microbiology · 2026Article
- Epidemiological baseline of Brucella spp. in South African wildlife.PLoS neglected tropical diseases · 2025Article
- Interactions between brucellosis and environmental factors: spatiotemporal epidemiology from Xinjiang, China.BMC public health · 2025Article
- Seropositivity and diagnostic challenges of bovine brucellosis in Limpopo and Free State (2013-2022).The Onderstepoort journal of veterinary research · 2025Article
- Seroprevalence and Associated Risk Factors of Human Brucellosis in a Farming and Animal Health Community in South Africa, 2015-2016.Tropical medicine and infectious disease · 2025Article
- Machine learning based on pangenome-wide association studies reveals the impact of host source on the zoonotic potential of closely related bacterial pathogens.Communications biology · 2025Article
104 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the genus Brucella are pathogenic bacteria exceedingly well adapted to their hosts. The bacterium is transmitted by direct contact within the same host species or accidentally to secondary hosts, such as humans. Human brucellosis is strongly linked to the management of domesticated animals and ingestion of their products. Since the domestication of ungulates and dogs in the Fertile Crescent and Asia in 12000 and 33000 ya, respectively, a steady supply of well adapted emergent Brucella pathogens causing zoonotic disease has been provided. Likewise, anthropogenic modification of wild life may have also impacted host susceptibility and Brucella selection. Domestication and human influence on wild life animals are not neutral phenomena. Consequently, Brucella organisms have followed their hosts' fate and have been selected under conditions that favor high transmission rate. The "arm race" between Brucella and their preferred hosts has been driven by genetic adaptation of the bacterium confronted with the evolving immune defenses of the host. Management conditions, such as clustering, selection, culling, and vaccination of Brucella preferred hosts have profound influences in the outcome of brucellosis and in the selection of Brucella organisms. Countries that have controlled brucellosis systematically used reliable smooth live vaccines, consistent immunization protocols, adequate diagnostic tests, broad vaccination coverage and sustained removal of the infected animals. To ignore and misuse tools and strategies already available for the control of brucellosis may promote the emergence of new Brucella variants. The unrestricted use of low-efficacy vaccines may promote a "false sense of security" and works towards selection of Brucella with higher virulence and transmission potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.