ReviewFrontiers in microbiology2014
Adaptation to high salt concentrations in halotolerant/halophilic fungi: a molecular perspective.
Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 127 citations in OpenAlex.
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- A case for monitoring fungi of clinical relevance at beaches: enterococci measures do not correlate with all disease risks.Environmental monitoring and assessment · 2026Article
- Stress-Induced Cross-Protection and Combined Stress Responses in Extremotolerant Black Yeasts.Journal of fungi (Basel, Switzerland) · 2026Article
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- Putative palm pathogens: Novel species and new host records of leaf disease-associated microfungi (Ascomycota) onMycoKeys · 2026Article
- Salt-Adapted Microorganisms: A Promising Resource for Novel Anti-Cancer Drug Discovery.Marine drugs · 2025Review
- Halophilic Fungi-Features and Potential Applications.Microorganisms · 2025Review
- Regulation of Catalase Expression and Activity byJournal of fungi (Basel, Switzerland) · 2024Article
- Material Composition Characteristics ofMolecules (Basel, Switzerland) · 2024Article
- Hidden Treasure: Halophilic Fungi as a Repository of Bioactive Lead Compounds.Journal of fungi (Basel, Switzerland) · 2024Review
- Black yeasts in hypersaline conditions.Applied microbiology and biotechnology · 2024Review
- Influence of Salinity on the Extracellular Enzymatic Activities of Marine Pelagic Fungi.Journal of fungi (Basel, Switzerland) · 2024Article
- Structural adaptation of fungal cell wall in hypersaline environment.Nature communications · 2023Article
- The Cytotoxic Properties of Extreme Fungi's Bioactive Components-An Updated Metabolic and Omics Overview.Life (Basel, Switzerland) · 2023Review
- Alkaliphilic/Alkali-Tolerant Fungi: Molecular, Biochemical, and Biotechnological Aspects.Journal of fungi (Basel, Switzerland) · 2023Review
- Isolation and characterization of halophilic and halotolerant fungi from man-made solar salterns in Pattani Province, Thailand.PloS one · 2023Article
- Biophysical Manipulation of the Extracellular Environment byPathogens (Basel, Switzerland) · 2022Article
- A roadmap to understanding diversity and function of coral reef-associated fungi.FEMS microbiology reviews · 2022Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular studies of salt tolerance of eukaryotic microorganisms have until recently been limited to the baker's yeast Saccharomyces cerevisiae and a few other moderately halotolerant yeast. Discovery of the extremely halotolerant and adaptable fungus Hortaea werneckii and the obligate halophile Wallemia ichthyophaga introduced two new model organisms into studies on the mechanisms of salt tolerance in eukaryotes. H. werneckii is unique in its adaptability to fluctuations in salt concentrations, as it can grow without NaCl as well as in the presence of up to 5 M NaCl. On the other hand, W. ichthyophaga requires at least 1.5 M NaCl for growth, but also grows in up to 5 M NaCl. Our studies have revealed the novel and intricate molecular mechanisms used by these fungi to combat high salt concentrations, which differ in many aspects between the extremely halotolerant H. werneckii and the halophilic W. ichthyophaga. Specifically, the high osmolarity glycerol signaling pathway that is important for sensing and responding to increased salt concentrations is here compared between H. werneckii and W. ichthyophaga. In both of these fungi, the key signaling components are conserved, but there are structural and regulation differences between these pathways in H. werneckii and W. ichthyophaga. We also address differences that have been revealed from analysis of their newly sequenced genomes. The most striking characteristics associated with H. werneckii are the large genetic redundancy, the expansion of genes encoding metal cation transporters, and a relatively recent whole genome duplication. In contrast, the genome of W. ichthyophaga is very compact, as only 4884 protein-coding genes are predicted, which cover almost three quarters of the sequence. Importantly, there has been a significant increase in their hydrophobins, cell-wall proteins that have multiple cellular functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.