ArticleFrontiers in human neuroscience2014
Successful tactile based visual sensory substitution use functions independently of visual pathway integrity.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Gene-agnostic approaches to treating inherited retinal degenerations.Frontiers in cell and developmental biology · 2023Review
- Preparing participants for the use of the tongue visual sensory substitution device.Disability and rehabilitation. Assistive technology · 2022Article
- Current Modalities for Low Vision Rehabilitation.Cureus · 2021Review
- Brain-Machine Interfaces to Assist the Blind.Frontiers in human neuroscience · 2021Review
- Overlapping Anatomical Networks Convey Cross-Modal Suppression in the Sighted and Coactivation of "Visual" and Auditory Cortex in the Blind.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Current Approaches to Low Vision (Re)HabilitationTurkish journal of ophthalmology · 2019Review
- Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.NeuroImage. Clinical · 2017Article
- [Visual prostheses].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2016Review
- Article
- Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans.Neural regeneration research · 2015Article
- Diffusion Tensor Magnetic Resonance Imaging Strategies for Color Mapping of Human Brain Anatomy.Journal of medical signals and sensorsArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeNeuronal reorganization after blindness is of critical interest because it has implications for the rational prescription of artificial vision devices. The purpose of this study was to distinguish the microstructural differences between perinatally blind (PB), acquired blind (AB), and normally sighted controls (SCs) and relate these differences to performance on functional tasks using a sensory substitution device (BrainPort).
methodsWe enrolled 52 subjects (PB n = 11; AB n = 35; SC n = 6). All subjects spent 15 h undergoing BrainPort device training. Outcomes of light perception, motion, direction, temporal resolution, grating, and acuity were tested at baseline and after training. Twenty-six of the subjects were scanned with a three Tesla MRI scanner for diffusion tensor imaging (DTI), and with a positron emission tomography (PET) scanner for mapping regional brain glucose consumption during sensory substitution function. Non-parametric models were used to analyze fractional anisotropy (FA; a DTI measure of microstructural integrity) of the brain via region-of-interest (ROI) analysis and tract-based spatial statistics (TBSS).
resultsAt baseline, all subjects performed all tasks at chance level. After training, light perception, time resolution, location and grating acuity tasks improved significantly for all subject groups. ROI and TBSS analyses of FA maps show areas of statistically significant differences (p ≤ 0.025) in the bilateral optic radiations and some visual association connections between all three groups. No relationship was found between FA and functional performance with the BrainPort. DISCUSSION: All subjects showed performance improvements using the BrainPort irrespective of nature and duration of blindness. Definite brain areas with significant microstructural integrity changes exist among PB, AB, and NC, and these variations are most pronounced in the visual pathways. However, the use of sensory substitution devices is feasible irrespective of microstructural integrity of the primary visual pathways between the eye and the brain. Therefore, tongue based devices devices may be usable for a broad array of non-sighted patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.