ArticleFrontiers in behavioral neuroscience2014
Infant rats can learn time intervals before the maturation of the striatum: evidence from odor fear conditioning.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- The development of sniffing.Chemical senses · 2023Article
- Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala.Neuron · 2021Article
- Ultrasonic Vocalizations Emission across Development in Rats: Coordination with Respiration and Impact on Brain Neural Dynamics.Brain sciences · 2021Review
- Respiration and brain neural dynamics associated with interval timing during odor fear learning in rats.Scientific reports · 2020Article
- Developing a neurobehavioral animal model of poverty: Drawing cross-species connections between environments of scarcity-adversity, parenting quality, and infant outcome.Development and psychopathology · 2019Article
- Infant Trauma Alters Social Buffering of Threat Learning: Emerging Role of Prefrontal Cortex in Preadolescence.Frontiers in behavioral neuroscience · 2019Article
- Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats.Scientific reports · 2018Article
- Understanding pup affective state through ethologically significant ultrasonic vocalization frequency.Scientific reports · 2017Article
- Updating of aversive memories after temporal error detection is differentially modulated by mTOR across development.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Neurobehavioral assessment of maternal odor in developing rat pups: implications for social buffering.Social neuroscience · 2017Article
- Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring.Translational psychiatry · 2017Article
- Ecologically relevant neurobehavioral assessment of the development of threat learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Development of Odor Hedonics: Experience-Dependent Ontogeny of Circuits Supporting Maternal and Predator Odor Responses in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Developmental emergence of fear/threat learning: neurobiology, associations and timing.Genes, brain, and behavior · 2016Review
- Olfactory memory networks: from emotional learning to social behaviors.Frontiers in behavioral neuroscience · 2015Article
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11 authors.
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Abstract
Interval timing refers to the ability to perceive, estimate and discriminate durations in the range of seconds to minutes. Very little is currently known about the ontogeny of interval timing throughout development. On the other hand, even though the neural circuit sustaining interval timing is a matter of debate, the striatum has been suggested to be an important component of the system and its maturation occurs around the third post-natal (PN) week in rats. The global aim of the present study was to investigate interval timing abilities at an age for which striatum is not yet mature. We used odor fear conditioning, as it can be applied to very young animals. In odor fear conditioning, an odor is presented to the animal and a mild footshock is delivered after a fixed interval. Adult rats have been shown to learn the temporal relationships between the odor and the shock after a few associations. The first aim of the present study was to assess the activity of the striatum during odor fear conditioning using 2-Deoxyglucose autoradiography during development in rats. The data showed that although fear learning was displayed at all tested ages, activation of the striatum was observed in adults but not in juvenile animals. Next, we assessed the presence of evidence of interval timing in ages before and after the inclusion of the striatum into the fear conditioning circuit. We used an experimental setup allowing the simultaneous recording of freezing and respiration that have been demonstrated to be sensitive to interval timing in adult rats. This enabled the detection of duration-related temporal patterns for freezing and/or respiration curves in infants as young as 12 days PN during odor fear conditioning. This suggests that infants are able to encode time durations as well as and as quickly as adults while their striatum is not yet functional. Alternative networks possibly sustaining interval timing in infant rats are discussed.
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