ArticleFrontiers in behavioral neuroscience2014
Induction of aversive learning through thermogenetic activation of Kenyon cell ensembles in Drosophila.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 29 citations in OpenAlex.
- Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons.iScience · 2025Article
- The brain atlas of a subsocial bee reflects that of eusocial Hymenoptera.Genes, brain, and behavior · 2024Article
- Human TRPV1 is an efficient thermogenetic actuator for chronic neuromodulation.Cellular and molecular life sciences : CMLS · 2024Article
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- Polymer Physics-Based Classification of Neurons.Neuroinformatics · 2023Article
- Visualization of learning-induced synaptic plasticity in output neurons of the Drosophila mushroom body γ-lobe.Scientific reports · 2022Article
- Optogenetic and thermogenetic manipulation of defined neural circuits and behaviors inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior.Neuron · 2021Article
- Stochastic and Arbitrarily Generated Input Patterns to the Mushroom Bodies Can Serve as Conditioned Stimuli inFrontiers in physiology · 2020Article
- Selective suppression and recall of long-term memories in Drosophila.PLoS biology · 2019Article
- Differential regulation of theeLife · 2019Article
- Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila.Current opinion in neurobiology · 2018Review
- Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila.Nature communications · 2018Article
- Thermogenetic neurostimulation with single-cell resolution.Nature communications · 2017Article
- What genetic model organisms offer the study of behavior and neural circuits.Journal of neurogenetics · 2016Review
- Olfactory learning skews mushroom body output pathways to steer behavioral choice in Drosophila.Current opinion in neurobiology · 2015Review
- Light, heat, action: neural control of fruit fly behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Identified Serotonin-Releasing Neurons Induce Behavioral Quiescence and Suppress Mating in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila.eLife · 2014Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila represents a model organism to analyze neuronal mechanisms underlying learning and memory. Kenyon cells of the Drosophila mushroom body are required for associative odor learning and memory retrieval. But is the mushroom body sufficient to acquire and retrieve an associative memory? To answer this question we have conceived an experimental approach to bypass olfactory sensory input and to thermogenetically activate sparse and random ensembles of Kenyon cells directly. We found that if the artifical activation of Kenyon cell ensembles coincides with a salient, aversive stimulus learning was induced. The animals adjusted their behavior in a subsequent test situation and actively avoided reactivation of these Kenyon cells. Our results show that Kenyon cell activity in coincidence with a salient aversive stimulus can suffice to form an associative memory. Memory retrieval is characterized by a closed feedback loop between a behavioral action and the reactivation of sparse ensembles of Kenyon cells.
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