ArticleFrontiers in behavioral neuroscience2014
Lateral Habenula determines long-term storage of aversive memories.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Review: "The Disappointment Dilemma: Short- and Long-Term Learning From Negative Outcomes".The European journal of neuroscience · 2026Review
- Glutamatergic lateral habenula neurons modulate consolidation of associative memories.Frontiers in behavioral neuroscience · 2025Article
- Exploration of the white matter bundles connected to the pineal gland: A DTI study.Surgical and radiologic anatomy : SRA · 2024Article
- Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders.Frontiers in aging neuroscience · 2024Review
- Graph theory analysis reveals an assortative pain network vulnerable to attacks.Scientific reports · 2023Article
- Dynamics of Lateral Habenula-Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions.Neurology international · 2023Review
- Reward and aversion encoding in the lateral habenula for innate and learned behaviours.Translational psychiatry · 2022Review
- Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders.Frontiers in systems neuroscience · 2022Article
- Habenula GPR139 is associated with fear learning in the zebrafish.Scientific reports · 2021Article
- Habenula kisspeptin retrieves morphine impaired fear memory in zebrafish.Scientific reports · 2020Article
- Kisspeptin-1 regulates forebrain dopaminergic neurons in the zebrafish.Scientific reports · 2020Article
- Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats.Neuropharmacology · 2019Article
- Volume-Conducted Origin of the Field Potential at the Lateral Habenula.Frontiers in systems neuroscience · 2019Article
- mTORC1 controls long-term memory retrieval.Scientific reports · 2018Article
- Dysregulation of the Lateral Habenula in Major Depressive Disorder.Frontiers in synaptic neuroscience · 2018Review
- Neural, Cellular and Molecular Mechanisms of Active Forgetting.Frontiers in systems neuroscience · 2018Review
- Association between habenula dysfunction and motivational symptoms in unmedicated major depressive disorder.Social cognitive and affective neuroscience · 2017Article
- Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons.Addiction biology · 2017Article
- Activation of D1/5 Dopamine Receptors in the Dorsal Medial Prefrontal Cortex Promotes Incubated-Like Aversive Responses.Frontiers in behavioral neuroscience · 2017Article
- Molecular psychiatry of zebrafish.Molecular psychiatry · 2015Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The Lateral Habenula (LHb) is a small brain structure that codifies negative motivational value and has been related to major depression. It has been shown recently that LHb activation is sufficient to induce aversive associative learning; however the key question about whether LHb activation is required for an aversive memory to be formed has not been addressed. In this article we studied the function of the LHb in memory formation using the Inhibitory Avoidance task (IA). We found that LHb inactivation during IA training does not disrupt memory when assessed 24 h after, but abolishes it 7 days later, indicating that LHb activity during memory acquisition is not necessary for memory formation, but regulates its temporal stability. These effects suggest that LHb inactivation modifies subjective perception of the training experience.
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