ArticleFrontiers in neural circuits2014
The relative contributions of MNTB and LNTB neurons to inhibition in the medial superior olive assessed through single and paired recordings.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Computational Model for Synthesizing Auditory Brainstem Responses to Assess Neuronal Alterations in Aging and Autistic Animal Models.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.The Journal of comparative neurology · 2026Article
- Non-calyceal inputs gate the timing of calyx of Held evoked MNTB output.Communications biology · 2026Article
- Distinct cell classes in the superior paraolivary nucleus (SPN) region in the gerbil auditory brainstem revealed by in vivo physiological and anatomical characterization.Hearing research · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Obliteration of a glycinergic projection to the medial geniculate in an animal model of autism.Frontiers in cellular neuroscience · 2024Article
- Leveling up: a long-range olivary projection to the medial geniculate without collaterals to the central nucleus of the inferior colliculus in rats.Experimental brain research · 2022Article
- Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.Frontiers in neuroscience · 2022Article
- Sound source localization patterns and bilateral cochlear implants: Age at onset of deafness effects.PloS one · 2022Article
- In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity.Journal of visualized experiments : JoVE · 2020Article
- Excitatory-Inhibitory Synaptic Coupling in Avian Nucleus Magnocellularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Calyx of Held: A Hypothesis on the Need for Reliable Timing in an Intensity-Difference Encoder.Neuron · 2018Review
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- Neurotransmitters and Receptors Changes in Medial Nucleus of the Trapezoid Body (MNTB) of Early-Developmental Rats with Single-Side Deafness.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Optogenetic Control of Neural Circuits in the Mongolian Gerbil.Frontiers in cellular neuroscience · 2018Article
- Cellular Computations Underlying Detection of Gaps in Sounds and Lateralizing Sound Sources.Trends in neurosciences · 2017Review
- Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Amplitude Normalization of Dendritic EPSPs at the Soma of Binaural Coincidence Detector Neurons of the Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Octopus Cells in the Posteroventral Cochlear Nucleus Provide the Main Excitatory Input to the Superior Paraolivary Nucleus.Frontiers in neural circuits · 2017Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
The medial superior olive (MSO) senses microsecond differences in the coincidence of binaural signals, a critical cue for detecting sound location along the azimuth. An important component of this circuit is provided by inhibitory neurons of the medial and lateral nuclei of the trapezoid body (MNTB and LNTB, respectively). While MNTB neurons are fairly well described, little is known about the physiology of LNTB neurons. Using whole cell recordings from gerbil brainstem slices, we found that LNTB and MNTB neurons have similar membrane time constants and input resistances and fire brief action potentials, but only LNTB neurons fire repetitively in response to current steps. We observed that LNTB neurons receive graded excitatory and inhibitory synaptic inputs, with at least some of the latter arriving from other LNTB neurons. To address the relative timing of inhibition to the MSO from the LNTB versus the MNTB, we examined inhibitory responses to auditory nerve stimulation using a slice preparation that retains the circuitry from the auditory nerve to the MSO intact. Despite the longer physical path length of excitatory inputs driving contralateral inhibition, inhibition from both pathways arrived with similar latency and jitter. An analysis of paired whole cell recordings between MSO and MNTB neurons revealed a short and reliable delay between the action potential peak in MNTB neurons and the onset of the resulting IPSP (0.55 ± 0.01 ms, n = 4, mean ± SEM). Reconstructions of biocytin-labeled neurons showed that MNTB axons ranged from 580 to 858 μm in length (n = 4). We conclude that while both LNTB and MNTB neurons provide similarly timed inhibition to MSO neurons, the reliability of inhibition from the LNTB at higher frequencies is more constrained relative to that from the MNTB due to differences in intrinsic properties, the strength of excitatory inputs, and the presence of feedforward inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.