Evidence map›Paper›PMID 24860418›Full record

ArticleFrontiers in neuroscience2014

Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects.

Anke J Borgers, Karin E Koopman, Peter H Bisschop, Mireille J Serlie, Dick F Swaab, Eric Fliers, Susanne E la Fleur, Anneke Alkemade

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Orexin, serotonin, and energy balance.WIREs mechanisms of disease · 2022
    Review
  5. Serotonin, food intake, and obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anke J BorgersDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
Karin E KoopmanDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
Peter H BisschopDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
Mireille J SerlieDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
Dick F SwaabDepartment of Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences Amsterdam, Netherlands.
Eric FliersDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
Susanne E la FleurDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
Anneke AlkemadeDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands ; Cognitive Science Center Amsterdam, University of Amsterdam Amsterdam, Netherlands.
University of Amsterdam · NLAcademic Medical Center · NLNetherlands Institute for Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThat serotonin plays a role in the regulation of feeding behavior and energy metabolism has been known for a long time. Serotonin transporters (SERT) play a crucial role in serotonin signaling by regulating its availability in the synaptic cleft. The neuroanatomy underlying serotonergic signaling in humans is largely unknown, and until now, SERT immunoreactivity in relation to body weight has not been investigated.

objectiveTo clarify the distribution of SERT immunoreactivity throughout the human hypothalamus and to compare SERT immunoreactivity in the infundibular nucleus (IFN), the human equivalent of the arcuate nucleus, in lean and overweight subjects.

designFirst, we investigated the distribution of serotonin transporters (SERT) over the rostro-caudal axis of six post-mortem hypothalami by means of immunohistochemistry. Second, we estimated SERT immunoreactivity in the IFN of lean and overweight subjects. Lastly, double-labeling of SERT with Neuropeptide Y (NPY) and melanocortin cell populations was performed to further identify cells showing basket-like SERT staining.

resultsSERT-immunoreactivity was ubiquitously expressed in fibers throughout the hypothalamus and was the strongest in the IFN. Immunoreactivity in the IFN was lower in overweight subjects (p = 0.036). Basket-like staining in the IFN was highly suggestive of synaptic innervation. A very small minority of cells showed SERT double labeling with NPY, agouti-related protein and α-melanocyte stimulating hormone.

conclusionsSERT is ubiquitously expressed in the human hypothalamus. Strong SERT immunoreactivity, was observed in the IFN a region important for appetite regulation, in combination with lower SERT immunoreactivity in the IFN of overweight and obese subjects, may point toward a role for hypothalamic SERT in human obesity.

Indexed as

arcuate nucleushypothalamusobesityparaventricular nucleusSERT

Identifiers

PMID24860418
PMCPMC4030197
OpenAlexW2133605866

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.