Evidence map›Paper›PMID 24859643›Full record

ArticleNature materials2014

Internal dynamics of a supramolecular nanofibre.

Julia H Ortony, Christina J Newcomb, John B Matson, Liam C Palmer, Peter E Doan, Brian M Hoffman, Samuel I Stupp

Abstract read
In one paragraph

Article in Nature materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Rigid Supramolecular Aramid Nanotubes as Catalyst Supports.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  5. Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
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  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia H OrtonyInstitute for BioNanotechnology in Medicine, Northwestern University, 303 East Superior Street, Suite 11-131, Chicago, Illinois 60611, USA.
Christina J Newcomb1] Institute for BioNanotechnology in Medicine, Northwestern University, 303 East Superior Street, Suite 11-131, Chicago, Illinois 60611, USA [2] Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, USA.
John B Matson1] Institute for BioNanotechnology in Medicine, Northwestern University, 303 East Superior Street, Suite 11-131, Chicago, Illinois 60611, USA [2].
Liam C PalmerDepartment of Chemistry, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, USA.
Peter E DoanDepartment of Chemistry, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, USA.
Brian M HoffmanDepartment of Chemistry, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, USA.
Samuel I Stupp1] Institute for BioNanotechnology in Medicine, Northwestern University, 303 East Superior Street, Suite 11-131, Chicago, Illinois 60611, USA [2] Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, USA [3] Department of Chemistry, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, USA [4] Department of Medicine, Northwestern University, 251 East Huron Street, Chicago, Illinois 60611, USA.

Funding

TR&D Project 3P41EB001980 · NIBIB · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2003 to 2017
$16.3M
COBOGLOBINS: COBALT-SUBSTITUTED MYO- AND HEMOGLOBINSR01HL013531 · NHLBI · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 1985 to 2013
$7.7M
3D Differentiation of Mesenchymal Stem Cells in Peptide Amphiphile MatricesF32AR061955 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MATSON, JOHN B · 2011 to 2011
$48k
COBOGLOBINS: COBALT-SUBSTITUTED MYO- AND HEMOGLOBINSR37HL013531 · NHLBI · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 1989 to 1998
–
NHLBI NIH HHS HL-13531NHLBI NIH HHS R01 HL013531NIAMS NIH HHS 1F32AR06195501NIAMS NIH HHS F32 AR061955NIBIB NIH HHS P41 EB001980
6 · The paper itself

Abstract

A large variety of functional self-assembled supramolecular nanostructures have been reported over recent decades. The experimental approach to these systems initially focused on the design of molecules with specific interactions that lead to discrete geometric structures, and more recently on the kinetics and mechanistic pathways of self-assembly. However, there remains a major gap in our understanding of the internal conformational dynamics of these systems and of the links between their dynamics and function. Molecular dynamics simulations have yielded information on the molecular fluctuations of supramolecular assemblies, yet experimentally it has been difficult to obtain analogous data with subnanometre spatial resolution. Using site-directed spin labelling and electron paramagnetic resonance spectroscopy, we measured the conformational dynamics of a self-assembled nanofibre in water through its 6.7 nm cross-section. Our measurements provide unique insight for the design of supramolecular functional materials.

Indexed as

Circular DichroismCryoelectron MicroscopyDiffusionElectron Spin Resonance SpectroscopyKineticsMicroscopy, Electron, TransmissionMolecular ConformationMolecular Dynamics SimulationNanofibersPeptidesProtein Structure, SecondarySpin LabelsPeptidesSpin Labels

Identifiers

PMID24859643
PMCPMC4110180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.