ArticleBMJ case reports2014
A rare presentation of an ancient disease: scurvy presenting as orthostatic hypotension.
Article in BMJ case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports.BMC pulmonary medicine · 2024Pooled it
- Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Pooled it
- Efficacy of Ascorbic Acid, Thiamine, and Hydrocortisone Combination Therapy: Meta-analysis of Randomized Controlled Trials.In vivo (Athens, Greece)Pooled it
- Are the UK's vitamin C recommendations evidence-based? A critical comment.The British journal of nutrition · 2026Review
- Article
- Intravenous Ascorbic Acid for the Prevention of Postreperfusion Syndrome in Orthotopic Liver Transplantation: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Scurvy: A Case Report and Literature Review.Cureus · 2021Article
- Article
- Case 22-2018: A 64-Year-Old Man with Progressive Leg Weakness, Recurrent Falls, and Anemia.The New England journal of medicine · 2018Article
- A simple method for plasma total vitamin C analysis suitable for routine clinical laboratory use.Nutrition journal · 2016Article
- Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?Critical care (London, England) · 2015Article
- Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 49-year-old man presented to hospital with severe orthostatic hypotension, gingival dysplasia and a purpuric rash involving his extremities. The orthostatic hypotension failed to respond to fluids and, on the basis of physical examination and dietary history, the patient was given a preliminary diagnosis of scurvy (ascorbic acid deficiency). Serum ascorbic acid levels were undetectable and the orthostasis was resolved within 24 h of ascorbic acid replacement. The pathogenesis of orthostatic hypotension in the setting of scurvy appears to involve impaired catecholamine synthesis and attenuated vasomotor response to α-adrenergic stimulation. We believe that this case describes a rare presentation of scurvy and highlights a previously under-reported connection between scurvy and vasomotor instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.