ReviewMitochondrion2014
High-throughput sequencing in mitochondrial DNA research.
Review in Mitochondrion, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Article
- Maternal genetic structure and population affinities of the Sichuan Han Chinese based on whole mitochondrial genomes.BMC genomics · 2026Article
- Quantitation of human mitochondrial DNA and whole mtGenomes sequencing of fingernail/hair shaft samples.Forensic sciences research · 2025Article
- Application of Next-Generation Sequencing (NGS) Techniques for Selected Companion Animals.Animals : an open access journal from MDPI · 2024Review
- Insights into phylogenetic relationships and gene rearrangements: complete mitogenomes of two sympatric species in the genusZooKeys · 2024Article
- Two Complete Mitochondrial Genomes ofGenes · 2023Article
- Comparative analysis between highFrontiers in oncology · 2023Article
- Article
- Mitochondrial Genomes Provide New Phylogenetic and Evolutionary Insights into Psilidae (Diptera: Brachycera).Insects · 2022Article
- Complete Mitogenome ofJournal of nematology · 2022Article
- Predicting pathogenic non-coding SVs disrupting the 3D genome in 1646 whole cancer genomes using multiple instance learning.Scientific reports · 2021Article
- Applying genomic and transcriptomic advances to mitochondrial medicine.Nature reviews. Neurology · 2021Review
- An innovative data analysis strategy for accurate next-generation sequencing detection of tumor mitochondrial DNA mutations.Molecular therapy. Nucleic acids · 2021Article
- NGS-based accurate and efficient detection of circulating cell-free mitochondrial DNA in cancer patients.Molecular therapy. Nucleic acids · 2021Article
- Complete Mitochondrial Genome of Three Species of the GenusAnimals : an open access journal from MDPI · 2020Article
- A Novel Approach for the Identification of Pharmacogenetic Variants inJournal of clinical medicine · 2020Article
- Genetic and phenotypic landscape of the mitochondrial genome in the Japanese population.Communications biology · 2020Article
- Variations in the Mitochondrial Genome of a Goldfish-Like Hybrid [Koi Carp (♀) × Blunt Snout Bream (♂)] Indicate Paternal Leakage.Frontiers in genetics · 2020Article
- The mitochondrial genome of the ornate sheep tick, Dermacentor marginatus.Experimental & applied acarology · 2019Article
- The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects.Neurochemistry international · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Next-generation sequencing, also known as high-throughput sequencing, has greatly enhanced researchers' ability to conduct biomedical research on all levels. Mitochondrial research has also benefitted greatly from high-throughput sequencing; sequencing technology now allows for screening of all 16,569 base pairs of the mitochondrial genome simultaneously for SNPs and low level heteroplasmy and, in some cases, the estimation of mitochondrial DNA copy number. It is important to realize the full potential of high-throughput sequencing for the advancement of mitochondrial research. To this end, we review how high-throughput sequencing has impacted mitochondrial research in the categories of SNPs, low level heteroplasmy, copy number, and structural variants. We also discuss the different types of mitochondrial DNA sequencing and their pros and cons. Based on previous studies conducted by various groups, we provide strategies for processing mitochondrial DNA sequencing data, including assembly, variant calling, and quality control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.