ReviewToxins2014
Effect of deoxynivalenol and other Type B trichothecenes on the intestine: a review.
Review in Toxins, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
135 citing papers in PubMed, 2 syntheses or guidelines pooled it, 333 citations in OpenAlex.
- Pooled it
- Trichothecenes in Food and Feed, Relevance to Human and Animal Health and Methods of Detection: A Systematic Review.Molecules (Basel, Switzerland) · 2021Pooled it
- Host-Associated Distribution and Mycological Characteristics of Fusarium sambucinum Species Complex and Other Fusarium Species in Rice, Maize, and Weeds in Korea.The plant pathology journal · 2026Article
- Gut microbiota dysbiosis transmits deoxynivalenol toxicity and triggers liver inflammation.Journal of advanced research · 2026Article
- Research progress on the toxicological characteristics and biodegradation of deoxynivalenol and its derivatives.Archives of toxicology · 2026Review
- Protective Effects of Mycotoxin Biodegradation Agents on Pigeon Health and Gut Microbiota.Toxins · 2026Article
- Impacts of trichothecene mycotoxins on human colonic epithelial cells: molecular mechanisms and signaling pathways.Journal of advanced research · 2026Review
- Interactive effects of the feed-borne mycotoxin deoxynivalenol and a mixed-species Eimeria challenge on layer pullets during the transition to lay.Poultry science · 2026Article
- A New Frontier in Food Safety: Cold Plasma Strategies for Effective Control of Fungi and Mycotoxins.Toxins · 2026Review
- Feeding of Undocked Pigs: Effects of Feed Components and Feed Composition.Animals : an open access journal from MDPI · 2026Review
- Article
- Climate-stressed crop mycobiomes as pre-harvest sentinels of human mycotoxin exposure: an AI-enabled One Health framework linking dysbiosis, exposomics, and toxicopathology.Frontiers in systems biology · 2026Review
- Silent Saboteurs: Decoding Mycotoxins-From Chemistry and Prevalence to Health Risks, Detection, Management and Emerging Frontiers.Journal of fungi (Basel, Switzerland) · 2025Review
- Temporal Wheat Proteome Remodeling by Deoxynivalenol Reveals Novel Detoxification Signatures and Strategies Across Cultivars.Molecular & cellular proteomics : MCP · 2025Article
- UDP-glycosyltransferases alleviate the toxic effects of deoxynivalenol on the growth performance and gut damage of Kunming mice.Scientific reports · 2025Article
- Exposure of broiler chickens to deoxynivalenol and Campylobacter jejuni induces substantial changes in intestinal gene expression.Scientific reports · 2025Article
- Article
- Genetic and Genomic Tools in Breeding for Resistance to Fusarium Stalk Rot in Maize (Plants (Basel, Switzerland) · 2025Review
- Compatibility and interference of food simulants and organic solvents with the in vitro toxicological assessment of food contact materials.Journal of food science · 2025Article
- Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural food contaminants, mycotoxins, are regarded as an important risk factor for human and animal health, as up to 25% of the world's crop production may be contaminated. The Fusarium genus produces large quantities of fusariotoxins, among which the trichothecenes are considered as a ubiquitous problem worldwide. The gastrointestinal tract is the first physiological barrier against food contaminants, as well as the first target for these toxicants. An increasing number of studies suggest that intestinal epithelial cells are targets for deoxynivalenol (DON) and other Type B trichothecenes (TCTB). In humans, various adverse digestive symptoms are observed on acute exposure, and in animals, these toxins induce pathological lesions, including necrosis of the intestinal epithelium. They affect the integrity of the intestinal epithelium through alterations in cell morphology and differentiation and in the barrier function. Moreover, DON and TCTB modulate the activity of intestinal epithelium in its role in immune responsiveness. TCTB affect cytokine production by intestinal or immune cells and are supposed to interfere with the cross-talk between epithelial cells and other intestinal immune cells. This review summarizes our current knowledge of the effects of DON and other TCTB on the intestine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.