ArticleThe Plant cell2014
PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 91 citations in OpenAlex.
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- BrPIF4/BrBBX24-BrHB52-mediated hypocotyl modularity unlocks mechanized harvesting potential inHorticulture research · 2026Article
- Tailored UV-A Irradiation and Callus Selection Enable Distinct Flavonoid Profile Production in Grape Cell Cultures.Foods (Basel, Switzerland) · 2026Article
- Light interacts with mechanical stress to regulate the seed-to-seedling transition.Stress biology · 2025Review
- Interaction of OsCSN2 with OsCULs Under Red and Far-Red Light Regulates Stem and Coleoptile Growth in Rice.Plants (Basel, Switzerland) · 2025Article
- How Histone Acetyltransferases Shape Plant Photomorphogenesis and UV Response.International journal of molecular sciences · 2024Review
- COP1 controls light-dependent chromatin remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Overexpression of a pseudo-etiolated-in-light-like protein inFrontiers in plant science · 2023Article
- Emerging roles of the ubiquitin-proteasome pathway in enhancing crop yield by optimizing seed agronomic traits.Plant cell reports · 2022Review
- CONSTITUTIVE PHOTOMORPHOGENIC 1 promotes seed germination by destabilizing RGA-LIKE 2 in Arabidopsis.Plant physiology · 2022Article
- Mutual upregulation of HY5 and TZP in mediating phytochrome A signaling.The Plant cell · 2022Article
- Integration of Light and Brassinosteroid Signaling during Seedling Establishment.International journal of molecular sciences · 2021Review
- Phytochrome Signaling Networks.Annual review of plant biology · 2021Review
- Direct phosphorylation of HY5 by SPA kinases to regulate photomorphogenesis in Arabidopsis.The New phytologist · 2021Article
- The transcription factor SlHY5 regulates the ripening of tomato fruit at both the transcriptional and translational levels.Horticulture research · 2021Article
- Protein Kinase Activity of Phytochrome A Positively Correlates With Photoresponses in Arabidopsis.Frontiers in plant science · 2021Article
- Illuminating the COP1/SPA Ubiquitin Ligase: Fresh Insights Into Its Structure and Functions During Plant Photomorphogenesis.Frontiers in plant science · 2021Review
- Plant Defense Responses to Biotic Stress and Its Interplay With Fluctuating Dark/Light Conditions.Frontiers in plant science · 2021Review
- HY5: A Pivotal Regulator of Light-Dependent Development in Higher Plants.Frontiers in plant science · 2021Review
- SPAs promote thermomorphogenesis by regulating the phyB-PIF4 module inDevelopment (Cambridge, England) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) is a RING/WD40 repeat-containing ubiquitin E3 ligase that is conserved from plants to humans. COP1 forms complexes with SUPPRESSOR OF PHYTOCHROME A (SPA) proteins, and these complexes degrade positively acting transcription factors in the dark to repress photomorphogenesis. Phytochrome-interacting basic helix-loop-helix transcription factors (PIFs) also repress photomorphogenesis in the dark. In response to light, the phytochrome family of sensory photoreceptors simultaneously inactivates COP1-SPA complexes and induces the rapid degradation of PIFs to promote photomorphogenesis. However, the functional relationship between PIFs and COP1-SPA complexes is still unknown. Here, we present genetic evidence that the pif and cop1/spa Arabidopsis thaliana mutants synergistically promote photomorphogenesis in the dark. LONG HYPOCOTYL5 (HY5) is stabilized in the cop1 pif1, spa123 pif1, and pif double, triple, and quadruple mutants in the dark. Moreover, the hy5 mutant suppresses the constitutive photomorphogenic phenotypes of the pifq mutant in the dark. PIF1 forms complexes with COP1, HY5, and SPA1 and enhances the substrate recruitment and autoubiquitylation and transubiquitylation activities of COP1. These data uncover a novel function of PIFs as the potential cofactors of COP1 and provide a genetic and biochemical model of how PIFs and COP1-SPA complexes synergistically repress photomorphogenesis in the dark.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.