Trial reportPloS one2014
Filaggrin gene mutation c.3321delA is associated with various clinical features of atopic dermatitis in the Chinese Han population.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Heterogeneity in Atopic Dermatitis: Ethnic, Anatomical Site, and Age-related Variations.Clinical reviews in allergy & immunology · 2026Review
- Atopic Dermatitis with Ichthyosis, Recurrent Fungal and Viral Infections: A Case of ConcurrentClinical, cosmetic and investigational dermatology · 2026Article
- Ichthyosis vulgaris: An updated review.Skin health and disease · 2023Review
- Atopic dermatitis: molecular, cellular, and clinical aspects.Molecular biology reports · 2022Review
- FLG Is a Potential Biomarker of Prognosis and Immunotherapy in Skin Cutaneous Melanoma.Applied bionics and biomechanics · 2022Article
- Skin barrier defects in atopic dermatitis: From old idea to new opportunity.Allergology international : official journal of the Japanese Society of Allergology · 2022Review
- Practical Recommendations for the Topical Treatment of Atopic Dermatitis in South and East Asia.Dermatology and therapy · 2021Article
- Cytokines and apoptosis in atopic dermatitis.Postepy dermatologii i alergologii · 2021Review
- Filaggrin and atopic march.Biochemia medica · 2019Review
- Epithelial barrier repair and prevention of allergy.The Journal of clinical investigation · 2019Review
- Filaggrin Mutation in Korean Patients with Atopic Dermatitis.Yonsei medical journal · 2017Article
- Association of FLG single nucleotide variations with clinical phenotypes of atopic dermatitis.PloS one · 2017Article
- Development of Unlabeled Probe Based High-Resolution Melting Analysis for Detection of Filaggrin Gene Mutation c.3321delA.Journal of clinical laboratory analysis · 2016Article
- Filaggrin Gene Mutation c.3321delA is Associated with Dry Phenotypes of Atopic Dermatitis in the Chinese Han Population.Chinese medical journal · 2016Article
- Genetic and epigenetic studies of atopic dermatitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Review
- Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe confirmed that the filaggrin gene mutation c.3321delA is associated with atopic dermatitis in our previous genome wide association study of the Chinese Han population. c.3321delA is the most common filaggrin gene mutation in Chinese atopic dermatitis patients but is not present in European populations.
objectiveTo investigate the genetic model for the c.3321delA mutation and to determine the correlation between c.3321delA and atopic dermatitis clinical phenotypes in the Chinese Han population.
methodThe filaggrin gene mutation c.3321delA was sequenced in 1,080 atopic dermatitis patients and 908 controls from the Chinese population. The χ2 test, ANOVA,nonparametric tests and logistic regression were used to investigate the relationship between the c.3321delA genotype and atopic dermatitis clinical phenotypes in the Chinese Han population.
resultsAnalyses of the genetic model revealed that the additive model best described the c.3321delA mutation (P = 3.09E-11, OR = 3.43, 95%CI = 2.38-4.96). Stratified analyses showed that the c.3321delA allele frequency distribution is significantly associated with concomitant skin xerosis (P = 1.68E-03, OR = 2.13,95%CI = 1.32-3.46), palmar hyperlinearity (P = 3.64E-17, OR = 4.0,95%CI = 2.86-5.70), white dermatographism (P = 4.25E-03, OR = 1.82,95%CI = 1.22-2.71), food intolerance (P = 1.51E-03, OR = 1.76,95%CI = 1.23-2.50) and disease severity ( P = 9.67E-05).
conclusionOur study indicates that the filaggrin gene mutation c.3321delA is associated with clinical phenotypes of atopic dermatitis in the Chinese Han population, which might help us gain a better understanding on the pathogenesis of atopic dermatitis.
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