ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: a retrospective analysis.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
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- Validation of 2-year 123I-meta-iodobenzylguanidine-based cardiac mortality risk model in chronic heart failure.European heart journal. Cardiovascular Imaging · 2018Article
- Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death.Cardiac electrophysiology clinics · 2017Review
- Dual isotope and multidetector camera: The best choices for a specific end-point.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Ventricular arrhythmias and autonomic nervous system: evolving role of radionuclide imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Standardization ofClinical and translational imaging · 2017Review
- Current Clinical Applications and Next Steps for Cardiac Innervation Imaging.Current cardiology reports · 2017Review
- The future of cardiac 123-I MIBG imaging.European journal of nuclear medicine and molecular imaging · 2016Article
- Life-Threatening Ventricular Arrhythmias: Current Role of Imaging in Diagnosis and Risk Assessment.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- It's not all in the numbers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Principles and techniques of imaging in identifying the substrate of ventricular arrhythmia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Prognostic Significance of Imaging Myocardial Sympathetic Innervation.Current cardiology reports · 2015Review
- Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 1 of 2: Positron emission tomography, computed tomography, and neuronal imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThe purpose of this study is to assess mIBG uptake in scar border zone and its relation with ventricular arrhythmia (VA) inducibility on electrophysiology (EP) testing using I-123 mIBG SPECT and resting Tc-99m SPECT myocardial perfusion imaging (MPI).
methodsForty-seven patients from a previous clinical trial were retrospectively analyzed. These patients underwent I-123 mIBG and resting Tc-99m tetrofosmin SPECT, and EP testing. Twenty-eight patients were positive (EP+) and 19 patients were negative (EP-) for inducibility of sustained (>30 seconds) VA on EP testing. MPI scar extent, border zone extent, and mIBG uptake in border zone were used to predict VA inducibility on EP testing, respectively.
resultsThere was no significant difference in scar extent between the EP+ and EP- groups. The EP+ group had significantly larger border zone and lower mIBG uptake ratio in the border zone than the EP- group. Receiver operating characteristic (ROC) curve analysis showed that the prediction accuracy for border zone extent (area under ROC = 0.75) was better than scar extent (area under ROC = 0.66). The prediction accuracy was further improved (area under ROC = 0.78), when assessing mIBG uptake in the border zone.
conclusionA new tool has been developed to measure scar and border zone and to assess mIBG uptake in scar and border zone from combined I-123 MIBG SPECT and resting Tc-99m SPECT MPI. The mIBG uptake in the border zone predicted VA inducibility on EP testing with a promising accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.