ArticleNutrients2014
Toxicity mechanisms of the food contaminant citrinin: application of a quantitative yeast model.
Article in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications.Biomedicines · 2026Review
- Food Toxicity of Mycotoxin Citrinin and Molecular Mechanisms of Its Potential Toxicity Effects through the Implicated Targets Predicted by Computer-Aided Multidimensional Data Analysis.Life (Basel, Switzerland) · 2023Article
- Detoxication of Citrinin with Kojic Acid by the Formation of the Citrinin-Kojic Acid Adduct, and the Enhancement of Kojic Acid Production by Citrinin via Oxidative Stress in Aspergillus parasiticusJournal of fungi (Basel, Switzerland) · 2022Article
- Postharvest Rot of Pomegranate Fruit in Southern Italy: Characterization of the Main Pathogens.Journal of fungi (Basel, Switzerland) · 2022Article
- Red yeast rice (Monascus purpureus) supplements: Case series assessment of spontaneously reported cases to The Netherlands Pharmacovigilance Centre Lareb.British journal of clinical pharmacology · 2021Article
- Citrinin in Foods and Supplements: A Review of Occurrence and Analytical Methodologies.Foods (Basel, Switzerland) · 2020Review
- Genomic and transcriptomic survey of an endophytic fungus Calcarisporium arbuscula NRRL 3705 and potential overview of its secondary metabolites.BMC genomics · 2020Article
- Article
- Nutraceuticals in hypercholesterolaemia: an overview.British journal of pharmacology · 2017Review
- Red Yeast Rice.Foods (Basel, Switzerland) · 2017Article
- Different Toxicity Mechanisms for Citrinin and Ochratoxin A Revealed by Transcriptomic Analysis in Yeast.Toxins · 2016Article
- Article
- Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycotoxins are important food contaminants and a serious threat for human nutrition. However, in many cases the mechanisms of toxicity for this diverse group of metabolites are poorly understood. Here we apply live cell gene expression reporters in yeast as a quantitative model to unravel the cellular defense mechanisms in response to the mycotoxin citrinin. We find that citrinin triggers a fast and dose dependent activation of stress responsive promoters such as GRE2 or SOD2. More specifically, oxidative stress responsive pathways via the transcription factors Yap1 and Skn7 are critically implied in the response to citrinin. Additionally, genes in various multidrug resistance transport systems are functionally involved in the resistance to citrinin. Our study identifies the antioxidant defense as a major physiological response in the case of citrinin. In general, our results show that the use of live cell gene expression reporters in yeast are a powerful tool to identify toxicity targets and detoxification mechanisms of a broad range of food contaminants relevant for human nutrition.
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