ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2014
The WNT signaling antagonist Dickkopf-1 directs lineage commitment and promotes survival of the preimplantation embryo.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 114 citations in OpenAlex.
- Effects of luteal blood flow on endometrial progesterone concentrations and gene expression in Japanese Black cows.The Journal of reproduction and development · 2025Article
- Effects of Regulating Hippo and Wnt on the Development and Fate Differentiation of Bovine Embryo.International journal of molecular sciences · 2024Article
- GDF-8 improvesFrontiers in cell and developmental biology · 2024Article
- Pressing needs and recent advances to enhance production of embryos in vitro in cattle.Animal reproduction · 2024Article
- Developmental Hurdles That Can Compromise Pregnancy during the First Month of Gestation in Cattle.Animals : an open access journal from MDPI · 2023Review
- Disruption of CSF2RA in the bovine preimplantation embryo reduces development and affects embryonic gene expression in utero.Reproduction & fertility · 2023Article
- Review: Some challenges and unrealized opportunities toward widespread use of the in vitro-produced embryo in cattle production.Animal : an international journal of animal bioscience · 2023Review
- Early embryonic lethality of mice lacking POLD2.Molecular reproduction and development · 2023Article
- Developmental competence of IVF and SCNT goat embryos is improved by inhibition of canonical WNT signaling.PloS one · 2023Article
- Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence.Frontiers in veterinary science · 2023Article
- Maternal contributions to pregnancy success: from gamete quality to uterine environment.Animal reproduction · 2023Article
- Overview of junctional complexes during mammalian early embryonic development.Frontiers in endocrinology · 2023Review
- Actions of WNT family member 5A to regulate characteristics of development of the bovine preimplantation embryo†.Biology of reproduction · 2022Article
- Bioactive supplements influencing bovine in vitro embryo development.Journal of animal science · 2022Review
- Actions of CSF2 and DKK1 on bovine embryo development and pregnancy outcomes are affected by composition of embryo culture medium.Scientific reports · 2022Article
- Pluripotent Core in Bovine Embryos: A Review.Animals : an open access journal from MDPI · 2022Review
- Increased expression of pro-inflammatory cytokines at the fetal-maternal interface in bovine pregnancies produced by cloning.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Article
- The Impact of Two Embryo Culture Media, Synthetic Oviduct Fluid and Commercial BO, on pre-and post-Implantation Development of Cloned SAANEN Goat Embryos.International journal of fertility & sterility · 2022Article
- Atlas of receptor genes expressed by the bovine morula and corresponding ligand-related genes expressed by uterine endometrium.Molecular reproduction and development · 2021Article
- Cytokines That Serve as Embryokines in Cattle.Animals : an open access journal from MDPI · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful embryonic development is dependent on factors secreted by the reproductive tract. Dickkopf-1 (DKK1), an antagonist of the wingless-related mouse mammary tumor virus (WNT) signaling pathway, is one endometrial secretory protein potentially involved in maternal-embryo communication. The purpose of this study was to investigate the roles of DKK1 in embryo cell fate decisions and competence to establish pregnancy. Using in vitro-produced bovine embryos, we demonstrate that exposure of embryos to DKK1 during the period of morula to blastocyst transition (between d 5 and 8 of development) promotes the first 2 cell fate decisions leading to increased differentiation of cells toward the trophectoderm and hypoblast lineages compared with that for control embryos treated with vehicle. Moreover, treatment of embryos with DKK1 or colony-stimulating factor 2 (CSF2; an endometrial cytokine known to improve embryo development and pregnancy establishment) between d 5 and 7 of development improves embryo survival after transfer to recipients. Pregnancy success at d 32 of gestation was 27% for cows receiving control embryos treated with vehicle, 41% for cows receiving embryos treated with DKK1, and 39% for cows receiving embryos treated with CSF2. These novel findings represent the first evidence of a role for maternally derived WNT regulators during this period and could lead to improvements in assisted reproductive technologies.
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