ArticleAmerican journal of obstetrics and gynecology2014
Sex-specific effects of maternal anthropometrics on body composition at birth.
Article in American journal of obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Placental gene signatures associated with high neonatal adiposity: role for immune cell activation.Journal of the Endocrine Society · 2026Article
- The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for "Sex Differences in Health Awareness Day".Biology of sex differences · 2025Review
- Article
- Effect of Maternal Pre-Pregnancy Body Mass Index on Longitudinal Fetal Growth and Mediating Role of Maternal Fasting Plasma Glucose: A Retrospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- The relationship between obesity-relatedFrontiers in nutrition · 2023Article
- The Prenatal Hormone Milieu in Autism Spectrum Disorder.Frontiers in psychiatry · 2021Review
- Let's Talk About Sex: Placentas' Central Role in Sexually Dimorphic Responses to the Maternal Milieu.The Journal of clinical endocrinology and metabolism · 2020Article
- A maternal "mixed, high sugar" dietary pattern is associated with fetal growth.Maternal & child nutrition · 2020Article
- Sex differences in fetal growth and immediate birth outcomes in a low-risk Caucasian population.Biology of sex differences · 2019Observational
- IL-1 receptor antagonist therapy mitigates placental dysfunction and perinatal injury following Zika virus infection.JCI insight · 2019Article
- Fetal sex modifies the effect of maternal macronutrient intake on the incidence of small-for-gestational-age births: a prospective observational cohort study.The American journal of clinical nutrition · 2018Observational
- Maternal overweight is not an independent risk factor for increased birth weight, leptin and insulin in newborns of gestational diabetic women: observations from the prospective 'EaCH' cohort study.BMC pregnancy and childbirth · 2018Observational
- Diabetes in pregnancy: a new decade of challenges ahead.Diabetologia · 2018Review
- Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero.Diabetologia · 2018Article
- Maternal pre-pregnancy BMI and offspring body composition in young adulthood: the modifying role of offspring sex and birth order.Public health nutrition · 2017Article
- Maternal Weight Gain Regulates Omega-3 Fatty Acids in Male, Not Female, Neonates.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity.Nutrients · 2017Article
- Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child.BMJ (Clinical research ed.) · 2017 · on this mapReview
- Sex-Specific Associations of Maternal Gestational Glycemia with Hormones in Umbilical Cord Blood at Delivery.American journal of perinatology · 2016Article
- Sex differences in the association of cord blood insulin with subcutaneous adipose tissue in neonates.International journal of obesity (2005) · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe purpose of this study was to assess whether maternal factors that are associated with fetal lean and fat mass differ between sexes. STUDY
designSecondary analysis of a prospective cohort that delivered by scheduled cesarean section from 2004-2013. Maternal blood was collected before surgery for metabolic parameters. Placental weight and neonatal anthropometrics were measured within 48 hours. Anthropometric differences between sexes were assessed with the Student t test. Multiple stepwise regression analysis assessed the relationship between independent maternal variables and neonatal lean body mass (LBM), fat mass (FM), or percentage of fat as dependent variables in male and female infants combined and separately.
resultsWe analyzed 360 women with normal glucose tolerance and a wide range of pregravid body mass index (16-64 kg/m(2)) and their offspring (male, 194; female, 166). Male infants had more FM (mean difference, 40 ± 18 g; P = .03) and LBM (mean difference, 158 ± 34 g; P < .0001) than female infants. Percentage of body fat and measured maternal variables did not differ between sexes. In both sexes, placental weight had the strongest correlation with both neonatal LBM and FM, which accounted for 20-39% of the variance. In male infants, maternal height, body mass index, and weight gain were significant predictors of both lean and fat mass. In female infants, plasma interleukin-6 and C-reactive protein, respectively, were associated independently with percentage of body fat and LBM.
conclusionOur findings suggest that the body composition and inflammatory environment of the mother modulate the metabolic fitness of neonates, as predicted by fat and lean mass, in a sex-specific manner.
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