ArticleApplied and environmental microbiology2014
Simultaneous fermentation of glucose and xylose to butanol by Clostridium sp. strain BOH3.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 73 citations in OpenAlex.
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- Application of fed-batch strategy to fully eliminate the negative effect of lignocellulose-derived inhibitors in ABE fermentation.Biotechnology for biofuels and bioproducts · 2024Article
- Fuelling the future of sustainable sugar fermentation across generations.Engineering biology · 2022Review
- Nitrogen, Amino Acids, and Carbon as Control Factors of Riboflavin Production by Novosphingobium panipatense-SR3 (MT002778).Current microbiology · 2021Article
- Open Culture Ethanol-Based Chain Elongation to Form Medium Chain Branched Carboxylates and Alcohols.Frontiers in bioengineering and biotechnology · 2021Article
- Genetic sensor-regulators functional in Clostridia.Journal of industrial microbiology & biotechnology · 2020Article
- Synthesis and Sustainability Evaluation of a Lignocellulosic Multifeedstock Biorefinery Considering Technical Performance Indicators.ACS omega · 2020Article
- Anaerobic reduction of europium by a Clostridium strain as a strategy for rare earth biorecovery.Scientific reports · 2019Article
- Butanol production from lignocellulosic biomass: revisiting fermentation performance indicators with exploratory data analysis.Biotechnology for biofuels · 2019Review
- The Draft Genome Sequence of Clostridium sp. Strain NJ4, a Bacterium Capable of Producing Butanol from Inulin Through Consolidated Bioprocessing.Current microbiology · 2018Article
- The Draft Genome Sequence of Thermophilic Thermoanaerobacterium thermosaccharolyticum M5 Capable of Directly Producing Butanol from Hemicellulose.Current microbiology · 2018Article
- The Draft Genome Sequence of Clostridium beijerinckii NJP7, a Unique Bacterium Capable of Producing Isopropanol-Butanol from Hemicellulose Through Consolidated Bioprocessing.Current microbiology · 2018Article
- Exploitation of novel wild type solventogenic strains for butanol production.Biotechnology for biofuels · 2018Review
- Engineering xylose metabolism in thraustochytrid T18.Biotechnology for biofuels · 2018Article
- Sustainable carbon sources for microbial organic acid production with filamentous fungi.Biotechnology for biofuels · 2017Article
- Metabolic Engineering Strategies for Co-Utilization of Carbon Sources in Microbes.Bioengineering (Basel, Switzerland) · 2016Review
- Biobutanol production from C5/C6 carbohydrates integrated with pervaporation: experimental results and conceptual plant design.Journal of industrial microbiology & biotechnology · 2016Article
- Hierarchy in pentose sugar metabolism in Clostridium acetobutylicum.Applied and environmental microbiology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellulose and hemicellulose constitute the major components in sustainable feedstocks which could be used as substrates for biofuel generation. However, following hydrolysis to monomer sugars, the solventogenic Clostridium will preferentially consume glucose due to transcriptional repression of xylose utilization genes. This is one of the major barriers in optimizing lignocellulosic hydrolysates that produce butanol. Unlike studies on existing bacteria, this study demonstrates that newly reported Clostridium sp. strain BOH3 is capable of fermenting 60 g/liter of xylose to 14.9 g/liter butanol, which is similar to the 14.5 g/liter butanol produced from 60 g/liter of glucose. More importantly, strain BOH3 consumes glucose and xylose simultaneously, which is shown by its capability for generating 11.7 g/liter butanol from a horticultural waste cellulosic hydrolysate containing 39.8 g/liter glucose and 20.5 g/liter xylose, as well as producing 11.9 g/liter butanol from another horticultural waste hemicellulosic hydrolysate containing 58.3 g/liter xylose and 5.9 g/liter glucose. The high-xylose-utilization capability of strain BOH3 is attributed to its high xylose-isomerase (0.97 U/mg protein) and xylulokinase (1.16 U/mg protein) activities compared to the low-xylose-utilizing solventogenic strains, such as Clostridium sp. strain G117. Interestingly, strain BOH3 was also found to produce riboflavin at 110.5 mg/liter from xylose and 76.8 mg/liter from glucose during the fermentation process. In summary, Clostridium sp. strain BOH3 is an attractive candidate for application in efficiently converting lignocellulosic hydrolysates to biofuels and other value-added products, such as riboflavin.
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