ArticleMicrobiology (Reading, England)2014
Identification of a Salmonella ancillary copper detoxification mechanism by a comparative analysis of the genome-wide transcriptional response to copper and zinc excess.
Article in Microbiology (Reading, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The CueR-regulated transporters CopA and CusFABC coordinate copper detoxification inVirulence · 2025Article
- Crystal Structure and Functional Characterization of YjgK From Salmonella Typhimurium.Proteins · 2025Article
- The acquiredFrontiers in microbiology · 2024Article
- Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes.Metallomics : integrated biometal science · 2023Article
- Article
- Less is more: Enterobactin concentration dependency in copper tolerance and toxicity.Frontiers in molecular biosciences · 2022Article
- Evolution of Copper Homeostasis and Virulence inFrontiers in microbiology · 2022Article
- Copper Homeostatic Mechanisms and Their Role in the Virulence of Escherichia coli and Salmonella enterica.EcoSal Plus · 2021Review
- A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress.Metallomics : integrated biometal science · 2021Article
- Article
- Article
- The Role ofGenes · 2020Article
- Potential application of Pseudomonas stutzeri W228 for removal of copper and lead from marine environments.PloS one · 2020Article
- CpxR/CpxA ControlsJournal of bacteriology · 2018Article
- Transcriptome Response to Heavy Metals in Sinorhizobium meliloti CCNWSX0020 Reveals New Metal Resistance Determinants That Also Promote Bioremediation by Medicago lupulina in Metal-Contaminated Soil.Applied and environmental microbiology · 2017Article
- Copper homeostasis networks in the bacteriumThe Journal of biological chemistry · 2017Article
- Compartment and signal-specific codependence in the transcriptional control of Salmonella periplasmic copper homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Copper and zinc are essential metal ions, but toxic in excess. Bacteria have evolved different strategies to control their intracellular concentrations, ensuring proper supply while avoiding toxicity, including the induction of metal-specific as well as non-specific mechanisms. We compared the transcriptional profiles of Salmonella Typhimurium after exposure to either copper or zinc ions in both rich and minimal media. Besides metal-specific regulatory networks many global stress-response pathways react to an excess of either of these metal ions. Copper excess affects both zinc and iron homeostasis by inducing transcription of these metal-specific regulons. In addition to the control of zinc-specific regulons, zinc excess affects the Cpx regulon and the σ(E) envelope-stress responses. Finally, novel metal-specific upregulated genes were detected including a new copper-detoxification pathway that involves the siderophore enterobactin and the outer-membrane protein TolC. This work sheds light onto the transcriptional landscape of Salmonella after copper or zinc overload, and discloses a new mechanism of copper detoxification.
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