ArticleHearing research2014
Localization of kainate receptors in inner and outer hair cell synapses.
Article in Hearing research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Auditory hair cells and spiral ganglion neurons regenerate synapses with refined release properties in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing.Scientific reports · 2024Article
- Auditory Hair Cells and Spiral Ganglion Neurons Regenerate Synapses with Refined Release Properties In Vitro.bioRxiv : the preprint server for biology · 2023Article
- Diverse identities and sites of action of cochlear neurotransmitters.Hearing research · 2022Review
- ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment.European journal of human genetics : EJHG · 2022Article
- Cochlear Pathomorphogenesis of Incomplete Partition Type II in Slc26a4-Null Mice.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Acoustic Trauma Increases Ribbon Number and Size in Outer Hair Cells of the Mouse Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Physiopathological Relevance of D-Serine in the Mammalian Cochlea.Frontiers in cellular neuroscience · 2021Article
- Article
- Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons.Frontiers in cellular neuroscience · 2020Article
- Inhibition of the Adenosine ACells · 2019Article
- Characterization of transgenic mouse lines for labeling type I and type II afferent neurons in the cochlea.Scientific reports · 2019Article
- α-Actinin Anchors PSD-95 at Postsynaptic Sites.Neuron · 2018Article
- Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cellsNeural regeneration research · 2017Article
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Recent advances in the development and function of type II spiral ganglion neurons in the mammalian inner ear.Seminars in cell & developmental biology · 2017Review
- A GluD Coming-Of-Age Story.Trends in neurosciences · 2017Review
- Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation.Scientific reports · 2017Article
- Article
- Drug delivery into the cochlear apex: Improved control to sequentially affect finely spaced regions along the entire length of the cochlear spiral.Journal of neuroscience methods · 2016Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Glutamate plays a role in hair cell afferent transmission, but the receptors that mediate neurotransmission between outer hair cells (OHCs) and type II ganglion neurons are not well defined. A previous study using in situ hybridization showed that several kainate-type glutamate receptor (KAR) subunits are expressed in cochlear ganglion neurons. To determine whether KARs are expressed in hair cell synapses, we performed X-gal staining on mice expressing lacZ driven by the GluK5 promoter, and immunolabeling of glutamate receptors in whole-mount mammalian cochleae. X-gal staining revealed GluK5 expression in both type I and type II ganglion neurons and OHCs in adults. OHCs showed X-gal reactivity throughout maturation from postnatal day 4 (P4) to 1.5 months. Immunoreactivity for GluK5 in IHC afferent synapses appeared to be postsynaptic, similar to GluA2 (GluR2; AMPA-type glutamate receptor (AMPAR) subunit), while GluK2 may be on both sides of the synapses. In OHC afferent synapses, immunoreactivity for GluK2 and GluK5 was found, although GluK2 was only in those synapses bearing ribbons. GluA2 was not detected in adult OHC afferent synapses. Interestingly, GluK1, GluK2 and GluK5 were also detected in OHC efferent synapses, forming several active zones in each synaptic area. At P8, GluA2 and all KAR subunits except GluK4 were detected in OHC afferent synapses in the apical turn, and GluA2, GluK1, GluK3 decreased dramatically in the basal turn. These results indicate that AMPARs and KARs (GluK2/GluK5) are localized to IHC afferent synapses, while only KARs (GluK2/GluK5) are localized to OHC afferent synapses in adults. Glutamate spillover near OHCs may act on KARs in OHC efferent terminals to modulate transmission of acoustic information and OHC electromotility.
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